Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2
Tsatanetsatane wa Zamalonda
| CAS | 204656-20-2 | Molecular Formula | C172H265N43O51 |
| Kulemera kwa Maselo | 3751.20 | Maonekedwe | Choyera |
| Mkhalidwe Wosungira | Kukana kuwala, 2-8 digiri | Phukusi | Chikwama cha Aluminium zojambulazo / vial |
| Chiyero | ≥98% | Mayendedwe | Cold Chain ndi kutumiza kosungirako kozizira |
Zosakaniza za Liraglutide
Zomwe Zimagwira:
Liraglutide (analogue ya glucagon-ngati peptide-1 (GLP-1) yopangidwa ndi yisiti kudzera muukadaulo wophatikizanso ma genetic).
Dzina la Chemical:
Arg34Ls26-(N-e-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
Zosakaniza Zina:
Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid ndi/kapena Sodium Hydroxide (monga pH Adjusters Only), Phenol, ndi Madzi a jekeseni.
Kugwiritsa ntchito
Type 2 shuga mellitus
Liraglutide imathandizira kuwongolera shuga m'magazi.Imachepetsa hyperglycemia yokhudzana ndi chakudya (kwa maola 24 mutatha kudya) ndikuwonjezera katulutsidwe ka insulini (pokhapokha) ikafunika powonjezera kuchuluka kwa shuga, kuchedwa kutulutsa m'mimba, ndikupondereza katulutsidwe ka prandial glucagon.
Ndiwoyenera kwa odwala omwe shuga wawo wam'magazi akadali osayendetsedwa bwino pambuyo pa mlingo wokwanira wololedwa wa metformin kapena sulfonylureas okha.Amagwiritsidwa ntchito limodzi ndi metformin kapena sulfonylurea.
Imagwira ntchito modalira glucose, kutanthauza kuti imathandizira katulutsidwe ka insulini pokhapokha ngati milingo ya shuga m'magazi ikwera kuposa momwe imakhalira, kuteteza "kuchulukana".Chifukwa chake, zikuwonetsa chiopsezo chocheperako cha hypoglycemia.
Ili ndi kuthekera koletsa apoptosis ndikulimbikitsa kusinthika kwa maselo a beta (zowoneka m'maphunziro a nyama).
Amachepetsa chilakolako cha kudya ndikulepheretsa kulemera kwa thupi, monga momwe phunziro lamutu ndi mutu likuwonekera motsutsana ndi glimepiride.
Pharmacological Action
Liraglutide ndi analogi ya GLP-1 yokhala ndi 97% yotsatizana homology kwa GLP-1 yamunthu, yomwe imatha kumangirira ndikuyambitsa cholandilira cha GLP-1.GLP-1 receptor ndiye chandamale cha GLP-1, mahomoni amtundu wa incretin omwe amathandizira katulutsidwe ka insulini kuchokera ku ma cell a pancreatic β.Mosiyana ndi GLP-1 yakomweko, mbiri ya pharmacokinetic ndi pharmacodynamic ya liraglutide mwa anthu ndiyoyenera kumwa kamodzi patsiku.Pambuyo pa jekeseni wa subcutaneous, njira yake yogwiritsira ntchito nthawi yayitali imaphatikizapo: kudzigwirizanitsa komwe kumachepetsa kuyamwa;kumanga kwa albumin;Kukhazikika kwamphamvu kwa enzyme ndipo motero kutalika kwa plasma theka la moyo.
Ntchito ya liraglutide imayanjanitsidwa ndi kuyanjana kwake ndi GLP-1 receptor, zomwe zimapangitsa kuwonjezeka kwa cyclic adenosine monophosphate (cAMP).Liraglutide imathandizira katulutsidwe ka insulini m'njira yodalira shuga, pomwe imachepetsa katulutsidwe ka glucagon mopitilira mulingo wodalira shuga.
Chifukwa chake, shuga m'magazi akakwera, kutulutsa kwa insulin kumalimbikitsidwa, pomwe katulutsidwe ka glucagon kumalepheretsa.Mosiyana ndi izi, liraglutide imachepetsa katulutsidwe ka insulin panthawi ya hypoglycemia popanda kukhudza katulutsidwe ka glucagon.Dongosolo la hypoglycemic la liraglutide limaphatikizanso kukulitsidwa pang'ono kwa nthawi yotulutsa m'mimba.Liraglutide amachepetsa kulemera kwa thupi ndi kunenepa kwambiri pochepetsa njala komanso kudya mphamvu.
