Terlipressin Acetate ya Esophageal Variceal Bleeding
Tsatanetsatane wa Zamalonda
| Dzina | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| Nambala ya CAS | 14636-12-5 |
| Mapangidwe a maselo | Chithunzi cha C52H74N16O15S2 |
| Kulemera kwa maselo | 1227.37 |
| Nambala ya EINECS | 238-680-8 |
| Malo otentha | 1824.0±65.0 °C (Zonenedweratu) |
| Kuchulukana | 1.46±0.1 g/cm3(Zonenedweratu) |
| Zosungirako | Sungani pamalo amdima, m'malo opanda mpweya, Sungani mufiriji, pansi pa -15°C. |
| Acidity coefficient | (pKa) 9.90±0.15 (Zonenedweratu) |
Mawu ofanana ndi mawu
[N-α-Triglycyl-8-lysine] -vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein;1-Triglycyl-8-lysineVasopressin;Nα-Glycyl-glycyl-glycyl- [8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Mwachitsanzo, Terlipressin, Terlipressin, Terlipressin.
Kufotokozera
Terlipressin, dzina lake la mankhwala ndi triglycyllysine vasopressin, ndi mankhwala atsopano a vasopressin omwe amagwira kwa nthawi yayitali.Ndi mtundu wa prodrug, womwe sugwira ntchito wokha.Imapangidwa ndi aminopeptidase mu vivo "kutulutsa" pang'onopang'ono lysine vasopressin yogwira pambuyo pochotsa zotsalira za glycyl pa N-terminus yake.Chifukwa chake, terlipressin imakhala ngati nkhokwe yomwe imatulutsa lysine vasopressin pamlingo wokhazikika.
Mphamvu yamankhwala ya terlipressin ndikumanga minofu yosalala ya splanchnic ndikuchepetsa magazi a splanchnic (monga kuchepetsa kutuluka kwa magazi mu mesentery, ndulu, chiberekero, ndi zina), potero amachepetsa kuthamanga kwa magazi komanso kuthamanga kwa portal.Komano, itha kuchepetsa plasma Mphamvu ya renin ndende, potero kuonjezera aimpso magazi, kusintha aimpso ntchito ndi kuwonjezeka mkodzo linanena bungwe odwala hepatorenal syndrome.Terlipressin pakadali pano ndiye mankhwala okhawo omwe amatha kupititsa patsogolo kupulumuka kwa odwala omwe akukha magazi am'mimero.Amagwiritsidwa ntchito makamaka pochiza matenda a variceal hemorrhage.Kuphatikiza apo, terlipressin yagwiritsidwanso ntchito bwino pachiwindi ndi impso.Nthawi zambiri, zimakhala ndi gawo lopindulitsa pakukhazikika kwa refractory shock ndi cardiopulmonary resuscitation.Poyerekeza ndi vasopressin, imakhala ndi mphamvu yokhalitsa, sizimayambitsa zovuta zowopsa, kuphatikizapo fibrinolysis ndi zovuta kwambiri mu mtima wamtima, ndipo ndi yosavuta kugwiritsa ntchito (jekeseni wa mtsempha), yomwe ili yoyenera kwambiri pachimake komanso chisamaliro chovuta.Kupulumutsa ndi kuchiza odwala omwe akudwala kwambiri.
