Lineaclotide kusokonezeka kwa m'mimba 8511199-59-2

Lineaclotide ndi chimphepo cha Guanylance Cyclase-C redptor agonist (GCCA) ndi ma visceral analgesic ndi endocrine ntchito. Onse a Lineaclothide ndi metabolite amathamangitsidwa kwa chimbudzi cha Guanylat-C (gc-c) cholandirira pamtunda wa epithelium yaying'ono. Mu mitundu ya zinyama, Lineaclotide amachepetsa kupweteka kwa ma visceral kumayendedwe am'mimba kudzera pa kutsegula kwa GC-C, ndipo mwa anthu, mankhwalawa amawonjezera mayendedwe a atsanu. Zotsatira za kutsegula kwa GC-C zimachulukitsa ma intracellular ndi owonjezera cgmp (cyclic guonosine monophphathete) woipa. Kuchulukitsa CGMP ikhoza kuchepetsa ntchito ya ulusi wamanjenje ndikuchepetsa ululu wa ma visceral nyama. Mkati wa intracellur umatha kuwonjezera katulutsidwe ka cloride ndi bicarborbonate mu matumbo ang'onoang'ono (cystic fibrosis a traturec coulelator), omwe kenako amayambitsa chiwongola dzanja chaching'ono cha matumbo.