Linaclotide kwa Matenda a M'mimba 851199-59-2
Tsatanetsatane wa Zamalonda
| Dzina | Linaclotide |
| Nambala ya CAS | 851199-59-2 |
| Molecular formula | Chithunzi cha C59H79N15O21S6 |
| Kulemera kwa maselo | 1526.74 |
Mawu ofanana ndi mawu
Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteineyl-L-α-glutamyl-L-tyrosyl -L-cysteineyl-L-cysteineyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Kufotokozera
Linaclotide, kapangidwe ka peptide yopangidwa ndi 14 amino acid, imagwirizana ndi banja la endogenous guanosine peptide ndipo ndi mankhwala okhawo omwe amavomerezedwa ndi FDA a GC-C (guanylate) Cyclase-C) pochiza matenda opweteka a m'mimba omwe ali ndi kudzimbidwa (IBS-C) komanso akuluakulu odzimbidwa (CIC).
Chemical Properties
Linaclotide ndi ufa woyera mpaka woyera amorphous; kusungunuka pang'ono m'madzi ndi njira yamadzimadzi ya sodium chloride (0.9%).
Momwe zimagwirira ntchito
Linaclotide ndi guanylate cyclase-C receptor agonist (GCCA) yokhala ndi visceral analgesic ndi endocrine ntchito. Onse a linaclotide ndi metabolite yake yogwira amatha kumangirira ku guanylate cyclase-C (GC-C) cholandirira pa luminal pamwamba pa epithelium yaing'ono yamatumbo. M'zitsanzo za nyama, linaclotide imachepetsa ululu wa m'mimba ndikuwonjezera kuyenda kwa m'mimba kudzera mu kuyambitsa kwa GC-C, ndipo mwa anthu, mankhwalawa amawonjezeranso kuyenda kwa colonic. Zotsatira za kuyambitsa kwa GC-C ndikuwonjezeka kwa intracellular ndi extracellular cGMP (cyclic guanosine monophosphate). Extracellular cGMP ikhoza kuchepetsa ntchito ya mitsempha ya mitsempha ya ululu ndikuchepetsa kupweteka kwa visceral mu zinyama zachitsanzo. Intracellular cGMP imatha kuwonjezera kutulutsa kwa chloride ndi bicarbonate m'matumbo ang'onoang'ono poyambitsa CFTR (cystic fibrosis transmembrane conductance regulator), zomwe pamapeto pake zimabweretsa kuchulukira kwamadzi am'matumbo ang'onoang'ono komanso kuthamanga kwa matumbo ang'onoang'ono.
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