Atosiban Acetate Amagwiritsidwa Ntchito Pakubadwa Kwanthawi Zakale
Tsatanetsatane wa Zamalonda
| Dzina | Atosiban |
| Nambala ya CAS | 90779-69-4 |
| Mapangidwe a maselo | Chithunzi cha C43H67N11O12S2 |
| Kulemera kwa maselo | 994.19 |
| Nambala ya EINECS | 806-815-5 |
| Malo otentha | 1469.0±65.0 °C (Zonenedweratu) |
| Kuchulukana | 1.254±0.06 g/cm3(Zonenedweratu) |
| Zosungirako | -20 ° C |
| Kusungunuka | H2O:≤100 mg/mL |
Kufotokozera
Atosiban acetate ndi disulfide-bonded cyclic polypeptide yopangidwa ndi 9 amino acid.Ndi molekyulu ya oxytocin yosinthidwa pamalo 1, 2, 4 ndi 8. N-terminus ya peptide ndi 3-mercaptopropionic acid (thiol ndi Gulu la sulfhydryl la [Cys] 6 limapanga mgwirizano wa disulfide), C-terminal ndi mu mawonekedwe a amide, amino acid wachiwiri pa N-terminal ndi ethylated kusinthidwa [D-Tyr(Et)]2, ndi atosiban acetate ntchito mankhwala monga viniga Amapezeka mu mawonekedwe a asidi mchere, kawirikawiri. amadziwika kuti atosiban acetate.
Kugwiritsa ntchito
Atosiban ndi oxytocin ndi vasopressin V1A kuphatikiza cholandilira cholandirira, cholandilira cha oxytocin chimafanana ndi cholandirira cha vasopressin V1A.Pamene cholandilira cha oxytocin chatsekedwa, oxytocin imatha kugwirabe ntchito kudzera mu cholandilira cha V1A, kotero ndikofunikira kutsekereza njira ziwiri zomwe zili pamwambazi panthawi imodzi, ndipo kusagwirizana kumodzi kwa cholandilira chimodzi kumatha kuletsa kutsekeka kwa chiberekero.Ichinso ndi chimodzi mwa zifukwa zazikulu zomwe ma β-receptor agonists, calcium channel blockers ndi prostaglandin synthase inhibitors sangathe kuletsa bwino kutsekeka kwa uterine.
Zotsatira
Atosiban ndi oxytocin receptor antagonist ndi vasopressin V1A, mawonekedwe ake a mankhwala ndi ofanana ndi awiriwa, ndipo ali ndi chiyanjano chachikulu cha zolandilira, ndipo amapikisana ndi oxytocin ndi vasopressin V1A receptors, potero amalepheretsa njira ya oxytocin ndi vasopressin ndi kuchepetsa. zilonda zam'mimba.
