Ganirelix Acetate Peptide API

Kutulutsa kwamphamvu kwa gonadotropin-release hormone (GnRH) kumalimbikitsa kaphatikizidwe ndi katulutsidwe ka LH ndi FSH.Mafupipafupi a LH pulses pakati ndi mochedwa follicular magawo pafupifupi 1 pa ola.Ma pulse awa amawonetsedwa ndi kukwera kwakanthawi kwa seramu LH.Pakati pa nthawi ya msambo, kutulutsidwa kwakukulu kwa GnRH kumayambitsa LH.Kuthamanga kwa LH kwapakati pa msambo kungayambitse mayankho angapo a thupi, kuphatikizapo: ovulation, oocyte meiotic resumption, ndi corpus luteum mapangidwe.Kupanga kwa corpus luteum kumapangitsa kuchuluka kwa progesterone mu seramu, pomwe estradiol imatsika.Ganirelix acetate ndi wotsutsa wa GnRH yemwe amaletsa mpikisano wa GnRH receptors pa pituitary gonadotrophs ndi njira zotsatsira zotsatizana.Amapanga chopinga chofulumira, chosinthika cha katulutsidwe ka gonadotropin.Mphamvu yoletsa ya ganirelix acetate pa secretion ya LH ya pituitary inali yamphamvu kuposa ya FSH.Ganirelix acetate inalephera kuyambitsa kutulutsidwa koyamba kwa gonadotropins, zomwe zimagwirizana ndi kutsutsa.Kuchira kwathunthu kwa milingo ya LH ndi FSH ya pituitary kunachitika mkati mwa maola 48 pambuyo poti ganirelix acetate itathetsedwa.