Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU ndi molekyulu yopangira lipidated yolumikizira yomwe idapangidwira kuti iperekedwe ndi mankhwala omwe amalimbana ndi antibody-drug conjugates (ADCs). Imakhala ndi mchira wa stearoyl (Ste) hydrophobic, γ-glutamyl yolunjika, AEEA spacers for flexibility, ndi gulu la OSu (NHS ester) lolumikizana bwino.

 
Kafukufuku & Ntchito:

Amagwiritsidwa ntchito popanga ma prodrug synthesis ndi kapangidwe ka nanocarrier

Imawonjezera kuyanjana kwa ma cell komanso kutenga mankhwala

Imathandizira kulumikizidwa kwapaintaneti kutsamba la peptides, ma antibodies, kapena zonyamula

Zogulitsa (Gentolex Gulu):

Kuyera kwakukulu, okonzeka kugwirizanitsa NHS ester

Zoyenera pa bioconjugation komanso kafukufuku woperekedwa

Ste-γ-Glu-AEEA-AEEA-OSU ndiyabwino pakukonza dongosolo loperekera mankhwala.