Daptomycin 103060-53-3 kwa matenda opatsirana
Tsatanetsatane wa Zamalonda
| Dzina | Daptomycin |
| Nambala ya CAS | 103060-53-3 |
| Mapangidwe a maselo | C72H101N17O26 |
| Kulemera kwa maselo | 1620.67 |
| Nambala ya EINECS | 600-389-2 |
| Malo osungunuka | 202-204 ° C |
| Malo otentha | 2078.2±65.0 °C (Zonenedweratu) |
| Kuchulukana | 1.45±0.1 g/cm3(Zonenedweratu) |
| pophulikira | 87 ℃ |
| Zosungirako | Yosindikizidwa mu youma, Sungani mufiriji, pansi pa -20 ° C |
| Kusungunuka | Methanol: soluble5mg/mL |
| Acidity coefficient | (pKa) 4.00±0.10 (Zonenedweratu) |
| Fomu | ufa |
| Mtundu | wopanda mtundu mpaka kukomoka wachikasu |
Mawu ofanana ndi mawu
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R) -3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Kufotokozera
The maantibayotiki daptomycin ndi cyclic lipopeptide mankhwala ndi dongosolo latsopano yotengedwa nayo nayonso mphamvu msuzi wa Streptomyces (S. reseosporus), amene amalepheretsa biosynthesis wa bakiteriya cell khoma peptidoglycan ndi kusokoneza kayendedwe ka amino zidulo mu selo nembanemba.Kusintha mawonekedwe a cytoplasmic membrane kumatha kusokoneza magwiridwe antchito a bakiteriya m'njira zingapo ndikupha mwachangu mabakiteriya a Gram-positive.Kuphatikiza pa kuthekera kwake kuchitapo kanthu pa mabakiteriya a Gram-positive, daptomycin ndiyofunikira kwambiri pamagulu akutali omwe awonetsa kukana methicillin, vancomycin, ndi linezolid in vitro.Ili ndi ntchito zamphamvu, ndipo katunduyu ali ndi zofunikira kwambiri zachipatala kwa odwala omwe ali ndi vuto lalikulu.Chibayo cha Eosinophilic ndi matenda osowa komanso owopsa kwambiri okhala ndi zizindikiro monga kutentha thupi, chifuwa, kupuma movutikira, komanso kupuma movutikira.
Antibacterial Mphamvu
Daptomycin imakhala ndi ntchito yabwino yolimbana ndi mabakiteriya osiyanasiyana osamva maantibayotiki, monga MIC=0.06-0.5 μg/ml ya Staphylococcus aureus yolimbana ndi methicillin (MRSA), ndi Staphylococcus aureus (MRSA) yolimbana ndi methicillin.MIC=0.0625～1μg/ml ya mabakiteriya, MIC=0.12–0.5μg/ml ya Staphylococcus epidermidis yolimbana ndi oxacillin, MIC=2.5μg/ml ya enterococcus yolimbana kwambiri ndi maantibayotiki aminoglycoside, MIC/MICml-The GM2. wa Enterococcus ndi 0.5 ~ 1μg/ml, ndipo MIC ya Enterococcus yosamva mankhwala a glycopeptide ndi 1 ~ 2μg/ml.
