Caspofungin kwa Matenda a Antifungal
Tsatanetsatane wa Zamalonda
| Dzina | Caspofungin |
| Nambala ya CAS | 162808-62-0 |
| Mapangidwe a maselo | Chithunzi cha C52H88N10O15 |
| Kulemera kwa maselo | 1093.31 |
| Nambala ya EINECS | 1806241-263-5 |
| Malo otentha | 1408.1±65.0 °C (Zonenedweratu) |
| Kuchulukana | 1.36±0.1 g/cm3(Zonenedweratu) |
| Acidity coefficient | (pKa) 9.86±0.26 (Zonenedweratu) |
Mawu ofanana ndi mawu
CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy- L-ornithine] -5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Chemical Properties
Caspofungin anali woyamba echinocandin kuvomerezedwa kuchiza matenda oyamba ndi mafangasi.Kuyesa kwa in vitro ndi mu vivo kunatsimikizira kuti caspofungin ili ndi ntchito yabwino yolimbana ndi mabakiteriya ofunikira - Candida ndi Aspergillus.Caspofungin imatha kuphwanya khoma la cell poletsa kaphatikizidwe ka 1,3-β-glucan.Kuchipatala, caspofungin ali ndi zotsatira zabwino pa matenda a candidiasis osiyanasiyana ndi aspergillosis.
Zotsatira
(1,3) -D-glucan synthase ndi gawo lofunikira kwambiri la fungal cell wall synthesis, ndipo caspofungin imatha kukhala ndi antifungal effect poletsa mpikisano woletsa enzyme iyi.Pambuyo pa mtsempha wa magazi, ndende ya mankhwala a m'magazi a m'magazi imatsika mofulumira chifukwa cha kugawa kwa minofu, ndikutsatiridwa ndi kumasulidwa kwapang'onopang'ono kwa mankhwala ku minofu.Metabolism ya caspofungin inakula ndi kuchuluka kwa mlingo ndipo inali yokhudzana ndi mlingo panthawi yokhazikika ndi Mlingo wambiri.Chifukwa chake, kuti mukwaniritse machiritso othandiza komanso kupewa kudzikundikira kwa mankhwala, mlingo woyamba wotsitsa uyenera kuperekedwa ndikutsatiridwa ndi mlingo wokonza.Mukamagwiritsa ntchito cytochrome p4503A4 inducers nthawi imodzi, monga rifampicin, carbamazepine, dexamethasone, phenytoin, ndi zina zotero, tikulimbikitsidwa kuonjezera mlingo wokonza wa caspofungin.
Zizindikiro
Zizindikiro zovomerezeka za FDA za caspofungin zikuphatikizapo: 1. Kutentha kwa thupi ndi neutropenia: kumatanthauzidwa ngati: kutentha thupi > 38 ° C ndi chiwerengero chokwanira cha neutrophil (ANC) ≤500 / ml, kapena ndi ANC ≤1000 / ml ndipo zimanenedweratu kuti zikhoza kuchepetsedwa mpaka 500/ml.Malinga ndi malingaliro a Infectious Diseases Society of America (IDSA), ngakhale kuti odwala omwe ali ndi malungo osalekeza ndi neutropenia amathandizidwa ndi maantibayotiki ambiri, odwala omwe ali pachiwopsezo chachikulu amalimbikitsidwabe kugwiritsa ntchito empiric antifungal therapy, kuphatikiza caspofungin ndi mankhwala ena oletsa kutupa. ..2. Invasive candidiasis: IDSA imalimbikitsa echinocandins (monga caspofungin) monga mankhwala osankhidwa a candidiasis.Itha kugwiritsidwanso ntchito pochiza zilonda zam'mimba, peritonitis ndi matenda am'chifuwa omwe amayamba chifukwa cha matenda a Candida.3. Esophageal candidiasis: Caspofungin angagwiritsidwe ntchito pochiza matenda a candidiasis kwa odwala omwe amatsutsa kapena osalolera mankhwala ena.Kafukufuku wambiri wapeza kuti chithandizo cha caspofungin ndi chofanana ndi fluconazole.4. Aspergillosis yowononga: Caspofungin yavomerezedwa kuti ikhale yochizira aspergillosis kwa odwala omwe ali ndi tsankho, kukana, komanso kusagwira ntchito kwa mankhwala akuluakulu a antifungal, voriconazole.Komabe, echinocandin osavomerezeka ngati mankhwala oyamba.
