Zogulitsa

High Purity Peptides Retatrutide 10mg ya Kuchepetsa Kunenepa ndi Matenda a Shuga

Chiyero:> 99%

State: ufa wa Lyophilized

Maonekedwe: ufa woyera

Kufotokozera: 5mg/10mg/15mg/20mg/30mg

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Retatrutide

Retaglutide ndi mtundu watsopano wa dipeptidyl peptidase-4 (DPP-4) inhibitor class hypoglycemic mankhwala omwe angalepheretse kuwonongeka kwa glucagon-like peptide-1 (GLP-1) ndi glucose yodalira insulin-release polypeptide (GIP) ndi DPP-4 enzyme m'matumbo ndi magazi, kukulitsa ntchito yawo yachinsinsi, kukulitsa chinsinsi cha insulin, kukulitsa ntchito yawo yachinsinsi. mulingo woyambira wa insulin yosala kudya, ndikuchepetsa kutulutsa kwa glucagon ndi ma cell a pancreatic α, potero kuwongolera bwino shuga wamagazi a postprandial. Imachita bwino potengera zotsatira za hypoglycemic, kulolerana, komanso kutsata.

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Kuphatikizika kwa sodium

Inclisiran sodium API (Active Pharmaceutical Ingredient) imaphunziridwa makamaka m'munda wa RNA interference (RNAi) ndi mankhwala a mtima. Monga siRNA yokhala ndi mizere iwiri yolunjika ku jini ya PCSK9, imagwiritsidwa ntchito pofufuza zachipatala komanso zachipatala kuti awunike njira zochepetsera jini zochepetsera LDL-C (low-density lipoprotein cholesterol). Imagwiranso ntchito ngati gawo lachitsanzo pakufufuza njira zoperekera siRNA, kukhazikika, komanso njira zochizira za RNA zomwe zimayang'aniridwa ndi chiwindi.

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Fmoc-Gly-Gly-OH

Fmoc-Gly-Gly-OH ndi dipeptide yomwe imagwiritsidwa ntchito ngati maziko omangira mu solid-phase peptide synthesis (SPPS). Imakhala ndi zotsalira ziwiri za glycine ndi Fmoc-protected N-terminus, zomwe zimalola kuti peptide chain italike. Chifukwa chakuchepa kwa glycine komanso kusinthasintha kwake, dipeptide iyi nthawi zambiri imawerengedwa potengera kusinthika kwa msana wa peptide, kapangidwe ka maulalo, komanso kutengera mawonekedwe a peptide ndi mapuloteni.

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Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH ndi chomangira cha dipeptide chomwe chimagwiritsidwa ntchito kwambiri popanga peptide synthesis (SPPS). Gulu la Fmoc (9-fluorenylmethyloxycarbonyl) limateteza N-terminus, pamene gulu la tBu (tert-butyl) limateteza mbali ya hydroxyl ya threonine. dipeptide yotetezedwayi imaphunziridwa chifukwa cha gawo lake pothandizira kuti peptide italikidwe bwino, kuchepetsa kuthamanga kwamtundu, komanso kutengera mitundu yotsatizana pamapangidwe a mapuloteni ndi maphunziro oyanjana.

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AEEA-AEEA

AEEA-AEEA ndi hydrophilic, flexible spacer yomwe imagwiritsidwa ntchito pofufuza peptide ndi mankhwala osokoneza bongo. Zili ndi mayunitsi awiri a ethylene glycol, zomwe zimapangitsa kuti zikhale zothandiza pophunzira zotsatira za kutalika kwa linker ndi kusinthasintha pa kuyanjana kwa maselo, kusungunuka, ndi zochitika zamoyo. Ofufuza nthawi zambiri amagwiritsa ntchito mayunitsi a AEEA kuti awunike momwe ma spacers amakhudzira magwiridwe antchito a antibody-drug conjugates (ADCs), peptide-drug conjugates, ndi ma bioconjugates ena.

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Fmoc-L-Ls[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Pawiri izi ndi otetezedwa, functionalized lysine zotumphukira ntchito peptide kaphatikizidwe ndi mankhwala conjugate chitukuko. Imakhala ndi gulu la Fmoc la chitetezo cha N-terminal, ndi kusintha kwa unyolo wam'mbali ndi Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), ndi AEEA (aminoethoxyethoxyacetate). Zidazi zidapangidwa kuti ziphunzire za lipidation, chemistry ya spacer, komanso kutulutsidwa kwa mankhwala olamulidwa. Amafufuzidwa kwambiri potengera njira za mankhwala, zolumikizira za ADC, ndi ma peptides olumikizana ndi membrane.

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Fmoc-L-Ls[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Chophatikizika ichi ndi chochokera ku lysine chosinthidwa chomwe chimagwiritsidwa ntchito popanga peptide, makamaka popanga ma conjugates olunjika kapena amitundu yambiri. Gulu la Fmoc limalola kuphatikizika kwapang'onopang'ono kudzera pa Fmoc solid-phase peptide synthesis (SPPS). Unyolo wam'mbali umasinthidwa ndi chochokera ku stearic acid (Ste), γ-glutamic acid (γ-Glu), ndi zolumikizira ziwiri za AEEA (aminoethoxyethoxyacetate), zomwe zimapereka hydrophobicity, katundu wacharge, komanso malo osinthika. Amaphunziridwa nthawi zambiri chifukwa cha gawo lake pamakina operekera mankhwala, kuphatikiza ma antibody-drug conjugates (ADCs) ndi ma peptides olowa m'maselo.

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Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2

Zomwe Zimagwira:Liraglutide (analogue ya glucagon-ngati peptide-1 (GLP-1) yopangidwa ndi yisiti kudzera muukadaulo wa genetic recombination).

Dzina la Chemical:Arg34Lys26-(N-e-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]

Zosakaniza Zina:Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid ndi/kapena Sodium Hydroxide (monga pH Adjusters Only), Phenol, ndi Madzi a jekeseni.

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Leuprorelin Acetate Imayang'anira Kutulutsa kwa Ma Gonadal Hormones

Dzina: Leuprorelin

Nambala ya CAS: 53714-56-0

Mtundu wa molekyulu: C59H84N16O12

Kulemera kwa molekyulu: 1209.4

Nambala ya EINECS: 633-395-9

Kuzungulira kwachindunji: D25 -31.7° (c = 1 mu 1% acetic acid)

Kachulukidwe: 1.44±0.1 g/cm3(Zonenedweratu)

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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHndi tetrapeptide yotetezedwa yomwe imagwiritsidwa ntchito popanga peptide ndi maphunziro apangidwe. Gulu la Boc (tert-butyloxycarbonyl) limateteza N-terminus, pamene magulu a Trt (trityl) amateteza unyolo wam'mbali wa histidine ndi glutamine kuti ateteze zochita zosafunikira. Kukhalapo kwa Aib (α-aminoisobutyric acid) kumalimbikitsa ma helical conformations ndikuwonjezera kukhazikika kwa peptide. Peptide iyi ndiyofunikira pakufufuza kupindika kwa ma peptide, kukhazikika, komanso ngati scaffold popanga ma peptide omwe amagwira ntchito mwachilengedwe.

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BPC-157

BPC-157 API itengera njira ya solid phase synthesis (SPPS):
Kuyera kwakukulu: ≥99% (kuzindikira kwa HPLC)
Zotsalira zazing'ono zonyansa, palibe endotoxin, palibe kuipitsidwa kwachitsulo cholemera
Kukhazikika kwa batch, kubwereza mwamphamvu, kugwiritsa ntchito mlingo wa jakisoni
Thandizani magalamu ndi ma kilogalamu kuti mukwaniritse zosowa zamagawo osiyanasiyana kuchokera ku R&D kupita kumakampani.

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