Leuprorelin Acetate Imayang'anira Kutulutsa kwa Ma Gonadal Hormones
Tsatanetsatane wa Zamalonda
| Dzina | Leuprorelin |
| Nambala ya CAS | 53714-56-0 |
| Mapangidwe a maselo | Chithunzi cha C59H84N16O12 |
| Kulemera kwa maselo | 1209.4 |
| Nambala ya EINECS | 633-395-9 |
| Kuzungulira kwachindunji | D25 -31.7° (c = 1 mu 1% asidi asidi) |
| Kuchulukana | 1.44±0.1 g/cm3(Zonenedweratu) |
| Mkhalidwe wosungira | -15 ° C |
| Fomu | Zaukhondo |
| Acidity coefficient | (pKa) 9.82±0.15 (Zonenedweratu) |
| Kusungunuka kwamadzi | Kusungunuka m'madzi pa 1mg/ml |
Mawu ofanana ndi mawu
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTENHORMELEZINGH(LUTENHORMELEZINGH); DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-KUTULULIRA CHOFUNIKA;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)
Pharmacological Effect
Leuprolide, goserelin, triprelin, ndi nafarelin ndi mankhwala angapo omwe amagwiritsidwa ntchito nthawi zambiri m'chipatala kuchotsa mazira otsekemera pochiza khansa ya m'mawere isanakwane komanso khansa ya prostate.(otchedwa mankhwala a GnRH-a), mankhwala a GnRH-a amafanana ndi GnRH ndipo amapikisana ndi zolandilira GnRH za pituitary.Ndiko kuti, gonadotropin yotulutsidwa ndi pituitary imachepa, zomwe zimabweretsa kuchepa kwakukulu kwa mahomoni ogonana opangidwa ndi ovary.
Leuprolide ndi gonadotropin-release hormone (GnRH) analogi, peptide yopangidwa ndi 9 amino acid.Mankhwalawa amatha kulepheretsa kugwira ntchito kwa pituitary-gonadal system, kukana kwa michere ya proteolytic ndi kugwirizana kwa pituitary GnRH receptor ndi amphamvu kuposa GnRH, ndipo ntchito yolimbikitsa kutulutsidwa kwa timadzi ta luteinizing (LH) ndi pafupifupi nthawi za 20 pa GnRH.Ilinso ndi mphamvu yoletsa kwambiri pituitary-gonad kuposa GnRH.Mu gawo loyambirira la chithandizo, follicle stimulating hormone (FSH), LH, estrogen kapena androgen imatha kukulitsidwa kwakanthawi, kenako, chifukwa cha kuchepa kwa kuyankha kwa pituitary gland, kutulutsa kwa FSH, LH ndi estrogen kapena androgen kumaletsedwa. kumabweretsa kudalira mahomoni ogonana.Matenda ogonana (monga khansa ya prostate, endometriosis, etc.) ali ndi zotsatira zochiritsira.
Pakalipano, mchere wa acetate wa leuprolide umagwiritsidwa ntchito makamaka pachipatala, chifukwa ntchito ya leuprolide acetate imakhala yokhazikika kutentha kwa firiji.Madzi ayenera kutayidwa.Iwo angagwiritsidwe ntchito mankhwala castration mankhwala a endometriosis ndi uterine fibroids, chapakati precocious kutha msinkhu, premenopausal khansa ya m'mawere ndi kansa ya prostate, komanso zinchito uterine magazi amene contraindicated kapena osathandiza ochiritsira timadzi mankhwala.Angagwiritsidwenso ntchito ngati premedication pamaso endometrial resection, amene akhoza wogawana woonda endometrium, kuchepetsa edema, ndi kuchepetsa vuto la opaleshoni.
