Micafungin kwa antifungal ndi antiviral
Tsatanetsatane wa Zamalonda
| Dzina | Micafungin |
| Nambala ya CAS | 235114-32-6 |
| Molecular formula | Chithunzi cha C56H71N9O23S |
| Kulemera kwa maselo | 1270.28 |
| Nambala ya EINECS | 1806241-263-5 |
Clinical Pharmacology
Izi ndi za kulowetsedwa kwa mtsempha. The plasma ndende ukufika pazipita kumapeto kwa kulowetsedwa, ndi kuchotsa theka la moyo ndi 13.9 hours. Kuchuluka kwa micafungin m'mapapo, chiwindi, ndulu ndi minyewa yaimpso ndikokwera kwambiri, koma sikudziwika mu cerebrospinal fluid. Pambuyo mtsempha wa magazi kulowetsedwa, izo makamaka zimapukusidwa mu chiwindi ndi excreted mu ndowe ndi mkodzo.
Ntchito
Mlingo woyenera wochizira esophageal candidiasis ndi 150 mg patsiku, ndipo mlingo wovomerezeka wa kupewa matenda a Candida mu hematopoietic tsinde cell transplant odwala ndi 50 mg patsiku. Malinga ndi zomwe zilipo zachipatala, pafupifupi njira ya chithandizo kapena kupewa matenda awiriwa ndi masiku 15 ndi masiku 19, motero. Mankhwalawa amakonzedwa ndikuchepetsedwa ndi saline wamba kapena jekeseni wa 5% wa dextrose. Utsogoleri nthawi ayenera kukhala osachepera 1 ora, apo ayi n'zosavuta kubala chokhwima zochita.
Kuyanjana kwa Mankhwala
Pachimake plasma ndende ya nifedipine akhoza ziwonjezeke ndi 42%, ndipo ngati n`koyenera, kuganizira kuchepetsa mlingo wa nifedipine kapena discontinuing mankhwala. Dera lomwe lili pansi pa ndende ya plasma ya mankhwala oletsa kukana chiwalo Sirolimus lidakwera ndi 21%, ndipo kuchepetsa mlingo wa sirolimus kuyenera kuganiziridwa ngati koyenera. Antifungal mankhwala, mankhwala pharmacology, ntchito, chokhwima zochita, etc. wa micafungin
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