Leuprorelin Acetate Imayang'anira Kutulutsa kwa Ma Gonadal Hormones
Tsatanetsatane wa Zamalonda
| Dzina | Leuprorelin |
| Nambala ya CAS | 53714-56-0 |
| Molecular formula | Chithunzi cha C59H84N16O12 |
| Kulemera kwa maselo | 1209.4 |
| Nambala ya EINECS | 633-395-9 |
| Kuzungulira kwachindunji | D25 -31.7° (c = 1 mu 1% asidi asidi) |
| Kuchulukana | 1.44±0.1 g/cm3(Zonenedweratu) |
| Mkhalidwe wosungira | -15 ° C |
| Fomu | Zaukhondo |
| Acidity coefficient | (pKa) 9.82±0.15 (Zonenedweratu) |
| Kusungunuka kwamadzi | Kusungunuka m'madzi pa 1 mg/ml |
Mawu ofanana ndi mawu
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO -NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-KURELEACHIFUKWA;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(MUNTHU)
Pharmacological Effect
Leuprolide, goserelin, triprelin, ndi nafarelin ndi mankhwala angapo omwe amagwiritsidwa ntchito nthawi zambiri m'chipatala kuchotsa mazira otsekemera pochiza khansa ya m'mawere isanakwane komanso khansa ya prostate. (otchedwa mankhwala a GnRH-a), mankhwala a GnRH-a amafanana ndi GnRH ndipo amapikisana ndi zolandilira za pituitary GnRH. Ndiko kuti, gonadotropin yotulutsidwa ndi pituitary imachepa, zomwe zimabweretsa kuchepa kwakukulu kwa mahomoni ogonana opangidwa ndi ovary.
Leuprolide ndi gonadotropin-release hormone (GnRH) analogi, peptide yopangidwa ndi 9 amino acid. Mankhwalawa amatha kulepheretsa kugwira ntchito kwa pituitary-gonadal system, kukana kwa michere ya proteolytic ndi kugwirizana kwa pituitary GnRH receptor ndi amphamvu kuposa GnRH, ndipo ntchito yopititsa patsogolo kutulutsidwa kwa hormone ya luteinizing (LH) ndi pafupifupi 20 nthawi ya GnRH. Ilinso ndi mphamvu yoletsa kwambiri pituitary-gonad kuposa GnRH. Kumayambiriro kwa chithandizo, follicle stimulating hormone (FSH), LH, estrogen kapena androgen ikhoza kuwonjezeka kwakanthawi, ndiyeno, chifukwa cha kuchepa kwa kuyankha kwa pituitary gland, kutulutsa kwa FSH, LH ndi estrogen kapena androgen kumaletsedwa, zomwe zimapangitsa kudalira mahomoni ogonana. Matenda ogonana (monga khansa ya prostate, endometriosis, etc.) ali ndi zotsatira zochiritsira.
Pakalipano, mchere wa acetate wa leuprolide umagwiritsidwa ntchito makamaka kuchipatala, chifukwa ntchito ya leuprolide acetate imakhala yokhazikika kutentha kwa chipinda. Madzi ayenera kutayidwa. Iwo angagwiritsidwe ntchito mankhwala castration mankhwala a endometriosis ndi uterine fibroids, chapakati precocious kutha msinkhu, premenopausal khansa ya m'mawere ndi kansa ya prostate, komanso zinchito uterine magazi amene contraindicated kapena osathandiza ochiritsira timadzi mankhwala. Angagwiritsidwenso ntchito ngati premedication pamaso endometrial resection, amene akhoza wogawana woonda endometrium, kuchepetsa edema, ndi kuchepetsa vuto la opaleshoni.
