Caspofungin ya matenda a antifungal
Tsatanetsatane wazogulitsa
| Dzina | Caspofungin |
| Nambala ya cas | 162808-62-02-0 |
| Mawonekedwe a matope | C52H8N10O15 |
| Kulemera kwa maselo | 1093.31 |
| Nambala ya Einecs | 18062411-263-5 |
| Malo otentha | 1408.1 ± 65.0 ° C (Extrated) |
| Kukula | 1.36 ± 0,1 g / cm3 (kulosera) |
| Acidity zolimba | (PKA) 9.86 ± 0,26 (Oloseredwa) |
Mawuno
CS-1171; Caspofengine; Caspofungin; Caspongoungin; pnepocandinb0,1 - [1R, 5s) -N2- (10,12-Dimethyl -1-oxottradecyl) -4-hydroxy-l-lenithine] -5 - [3r) -3-hydrongine-0991; AIDS0150
Mankhwala
Caspofungin anali woyamba ku Echinocandin wovomerezedwa kuti athandizire matenda a fungus. Mu vitro ndipo mu zoyesera za Vivo adatsimikizira kuti Caspofengin ali ndi ntchito yabwino ya antibacteria ntchito yolimbana ndi moyo wofunikira - Canida ndi Asrrilgillus. Caspofungin imatha kufooka khoma la cell poletsa synthesis ya 1,3-β-glucan. Zachipatala, caspofungin imakhala ndi zotsatira zabwino pamankhwala a Cashidiasis ndi Aspergilosis.
Kukhudza
(1) Pambuyo pa mtsempha wa magazi, mankhwala a plasma amagwera mwachangu chifukwa cha magawidwe a shembo, kenako ndi kuwononga pang'onopang'ono kwa mankhwalawa. Kagayibolism ya caspofungin idakulirakulira mlingo wowonjezera ndipo anali wokhudzana ndi nthawi yokhazikika ndi milingo yambiri. Chifukwa chake, kuti mukwaniritse zochizira zothandiza komanso kupewa kudzikundikira kwa mankhwala, mlingo woyamba kukwezedwa uyenera kuperekedwa motsatiridwa ndi mlingo wokonza. Mukamagwiritsa ntchito cytochrome p4503a4 osafunsa nthawi yomweyo, monga rifampicin, carbamazupine, dexamethasone, phenytoin, ndi zina zowonjezera, ndi zina.
Umboni
FDA-Yovomerezeka ya Caspofungin ndi kuphatikiza: 1. Malinga ndi malingaliro a matenda opatsirana a America (IDSA), ngakhale odwala omwe ali ndi malungo omwe ali ndi vuto losatha, kuphatikizapo mankhwala ena a antifungin. . 2. Itha kugwiritsidwanso ntchito pochiza m'mimba m'mimba, peritonitis ndi chifuwa choyambitsidwa ndi matenda a Candida. 3. Kafukufuku angapo apeza kuti achire zotsatira za caspofungin amafanana ndi flucoconazole. 4.. Komabe, Echinocandin sakulimbikitsidwa ngati mankhwala oyamba.
