Carbetocin Kupewa Kutsekeka kwa Uterine ndi Kutaya Kutuluka kwa Postpartum
Tsatanetsatane wa Zamalonda
| Dzina | CARBETOCIN |
| Nambala ya CAS | 37025-55-1 |
| Molecular formula | Zithunzi za C45H69N11O12S |
| Kulemera kwa maselo | 988.17 |
| Nambala ya EINECS | 253-312-6 |
| Kuzungulira kwachindunji | D -69.0° (c = 0.25 mu 1M asidi asidi) |
| Malo otentha | 1477.9±65.0 °C (Zonenedweratu) |
| Kuchulukana | 1.218±0.06 g/cm3(Zonenedweratu) |
| Zosungirako | -15 ° C |
| Fomu | ufa |
Mawu ofanana ndi mawu
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBODBETWEENBUTYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Zochita zamoyo
Carbetocin, oxytocin (OT) analog, ndi oxytocin receptor agonist ndi Ki wa 7.1 nM. Carbetocin ali ndi kuyanjana kwakukulu (Ki = 1.17 μM) kwa chimeric N-terminus ya oxytocin receptor. Carbetocin ali ndi kuthekera kwa kafukufuku wa kukha magazi kwa postpartum. Carbetocin imatha kulowa chotchinga chamagazi-muubongo ndipo imakhala ngati antidepressant ngati kuyambitsa ma oxytocin receptors mu CNS.
Ntchito
Carbetocin ndi wopangidwa kwa nthawi yayitali oxytocin 8-peptide analogue yokhala ndi agonist katundu, ndipo mawonekedwe ake azachipatala komanso azachipatala amafanana ndi a oxytocin omwe amapezeka mwachilengedwe. Monga oxytocin, carbetocin imamangiriza ku timadzi tating'onoting'ono ta uterine yosalala, zomwe zimapangitsa kuti chiberekero chikhale chokhazikika, ndikuwonjezera ma frequency ake ndikuwonjezera kamvekedwe ka chiberekero pamaziko a kukomoka koyambirira. Miyezo ya oxytocin yolandirira m'chiberekero imakhala yochepa kwambiri panthawi yomwe sali oyembekezera, imawonjezeka panthawi yomwe ali ndi pakati, ndipo imafika pachimake panthawi yobereka. Choncho, carbetocin ilibe mphamvu pa chiberekero chosakhala ndi pakati, koma imakhala ndi mphamvu yamphamvu ya chiberekero pa chiberekero chapakati ndi chiberekero chatsopano.
Sinthani Zowongolera
Zosintha zimayendetsedwa motsatira ndondomeko. Kutengera momwe zimakhudzira komanso kuopsa kwake komanso kuopsa kwake, zosintha zimasankhidwa kukhala zazikulu, zazing'ono ndi malo. Kusintha kwa malo kumakhudza pang'ono chitetezo ndi khalidwe la mankhwala, choncho safuna kuvomereza ndi chidziwitso kwa kasitomala; Zosintha zazing'ono zimakhala ndi zotsatira zochepa pa chitetezo ndi khalidwe la mankhwala, ndipo ziyenera kudziwitsa makasitomala; Kusintha kwakukulu kumakhudza kwambiri chitetezo ndi khalidwe la mankhwala, ndipo zimafuna kuvomerezedwa ndi kasitomala.
Malinga ndi ndondomekoyi, kuwongolera kusintha kumayambika ndi ntchito yosintha momwe zosintha ndi zomveka zosinthira zimafotokozedwera. Kuwunikaku kumachitika potsatira kugwiritsa ntchito, komwe kumachitika ndi madipatimenti owongolera osintha. Pakadali pano, zowongolera zosintha zimagawidwa kukhala Major level, General level and Minor level. Pambuyo pakuwunidwa koyenera komanso kugawa, kuwongolera kusintha kwa magawo onse kuyenera kuvomerezedwa ndi QA Manager. Kuwongolera kusintha kumachitidwa pambuyo pa kuvomerezedwa malinga ndi ndondomeko ya ntchito. Kuwongolera kusintha kumatsekedwa pambuyo pa QA kutsimikizira kuti kusintha kwasintha kwakhazikitsidwa moyenera. Ngati zikuphatikiza zidziwitso za kasitomala, kasitomala ayenera kudziwitsidwa munthawi yake pambuyo povomereza kusintha kovomerezeka
