Bremelanotide
Bremelanotide API
Bremelanotidendi zopangiramelanocortin receptor agonistopangidwa kuti azichizahypoactive chilakolako chogonana (HSDD) in akazi premenopausal. Monga chithandizo choyamba chapakati chovomerezeka cha HSDD, Bremelanotide ikuyimira kupita patsogolo kwakukulu paumoyo wa amayi.
Kuvomerezedwa ndi US FDA mu 2019 pansi pa dzina lachidziwitsoVyleesi, Bremelanotide imapereka yankho lofunidwa, lopanda mahomoni kwa amayi omwe akukumana ndi kusowa chilakolako chogonana, chomwe sichingafotokozedwe ndi nkhani zachipatala, zamaganizo, kapena zaubwenzi.
ZathuBremelanotide APIamapangidwa kudzera mu kaphatikizidwe kolimba-gawo la peptide (SPPS), kuwonetsetsa chiyero chapamwamba, zonyansa zochepa, komanso kusasinthika koyenera jekeseni zamankhwala ndi zamalonda.
Njira Yochitira
Bremelanotide imagwira ntchito ndikuyambitsa melanocortin receptors, makamakaMC4R (melanocortin-4 cholandilira)muchapakati mantha dongosolo. Kutsegula uku kumakhulupirira kuti kumasintha njira muzochitahypothalamuszomwe zimakhudzidwa ndi chilakolako cha kugonana ndi chilakolako.
Zotsatira zazikulu ndi izi:
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Kuwongoleredwachizindikiro cha dopaminergic, kulimbikitsa chilakolako cha kugonana
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Kuchepetsa njira zoletsa zomwe zimakhudza libido
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Kusinthasintha kwa dongosolo lamanjenje lapakatipopanda kudalira mahomoni ogonana (non-estrogenic, non-testosterone)
Dongosololi limapangitsa Bremelanotide kukhala yosiyana ndi machiritso achikhalidwe komanso oyenera kwa azimayi ambiri.
Kafukufuku wa Zachipatala & Zotsatira
Bremelanotide adawunikidwa kangapoMayesero azachipatala a Phase 2 ndi Phase 3, kuphatikizapo zikwi za amayi omwe anapezeka ndi HSDD.
Zotsatira zazikulu ndi izi:
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Kuwongolera kofunikiramuzolinga zogonana (zoyesedwa ndi FSFI-d)
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Kuchepetsa kupsinjika kokhudzana ndi chilakolako chochepa chogonana (choyesedwa ndi FSDS-DAO)
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Kuyamba mwachangu(m'maola ochepa), kulolakugwiritsa ntchito pofunidwa musanayambe kugonana
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Kuwonetsa mphamvu mwa amayindi komanso popanda comorbid mikhalidwe(mwachitsanzo, kukhumudwa, nkhawa)
M'maphunziro azachipatala, mpaka25-35%odwala adawona kusintha kwakukulu poyerekeza ndi placebo.
Chitetezo ndi Kulekerera
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Ambiri zotsatira zoyipa monganseru, kuwotcha,ndimutu-kawirikawiri wofatsa komanso wodziletsa.
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Mosiyana ndi othandizira a melanocortin, Bremelanotide ndiosagwirizana ndi kuwonjezeka kwakukulu kwa kuthamanga kwa magazi kapena kugunda kwa mtimamwa odwala ambiri.
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Monga chithandizo chofunidwa, chimapewa kuwonetseredwa kwa mahomoni osatha ndipo chingagwiritsidwe ntchito mosinthika.
Kupanga ndi Ubwino
ZathuBremelanotide API:
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Amapangidwa pogwiritsa ntchito SPPS yapamwamba kwambiri
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Imakwaniritsa miyezo yapadziko lonse lapansi yakuyera, kudziwika, ndi zosungunulira zotsalira
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Ndioyenera kupanga jakisoni (monga zolembera zodzaza ndi autoinjector)
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Ikupezeka muoyendetsa ndi magulu amalonda, kuthandizira zonse za R&D komanso kupezeka kwa msika
Achire Mphamvu
Kupitilira HSDD, njira ya Bremelanotide yapangitsa chidwi kumadera ena akugonana ndi neuroendocrine modulation, kuphatikizapo:
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Kusokonekera kwa amuna
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Matenda okhudzana ndi maganizo
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Kukula ndi kuwongolera mphamvu (kudzera pa melanocortin system)
Mbiri yake ya peptide yodziwika bwino komanso zochitika zapakati zamanjenje zikupitilizabe kuthandizira chitukuko chomwe chili pafupi ndi madera ochiritsira.
