Atosiban Acetate Amagwiritsidwa Ntchito Pakubadwa Kwapanthawi Yasanakwane
Tsatanetsatane wa Zamalonda
| Dzina | Atosiban |
| Nambala ya CAS | 90779-69-4 |
| Molecular formula | Chithunzi cha C43H67N11O12S2 |
| Kulemera kwa maselo | 994.19 |
| Nambala ya EINECS | 806-815-5 |
| Malo otentha | 1469.0±65.0 °C (Zonenedweratu) |
| Kuchulukana | 1.254±0.06 g/cm3(Zonenedweratu) |
| Zosungirako | -20 ° C |
| Kusungunuka | H2O:≤100 mg/mL |
Kufotokozera
Atosiban acetate ndi disulfide-bonded cyclic polypeptide yopangidwa ndi 9 amino acid. Ndi molekyulu ya oxytocin yosinthidwa pa malo 1, 2, 4 ndi 8. N-terminus ya peptide ndi 3-mercaptopropionic acid (thiol ndi Gulu la sulfhydryl la [Cys] 6 limapanga mgwirizano wa disulfide), C-terminal ili mu mawonekedwe a amide, amino acid yachiwiri ndi D-terminal ndi D-terminal (D-terminal) ndipo atosiban acetate amagwiritsidwa ntchito m'mankhwala ngati viniga Amapezeka ngati mchere wa asidi, womwe umadziwika kuti atosiban acetate.
Kugwiritsa ntchito
Atosiban ndi oxytocin ndi vasopressin V1A kuphatikiza cholandilira cholandirira, cholandilira cha oxytocin chimakhala chofanana ndi cholandirira cha vasopressin V1A. Pamene cholandilira cha oxytocin chatsekedwa, oxytocin imathabe kuchitapo kanthu kudzera mu cholandilira cha V1A, kotero ndikofunikira kutsekereza njira ziwiri zomwe zili pamwambazi panthawi imodzi, ndipo kusagwirizana kumodzi kwa cholandilira chimodzi kumatha kuletsa kutsekeka kwa chiberekero. Ichinso ndi chimodzi mwazifukwa zazikulu zomwe ma β-receptor agonists, calcium channel blockers ndi prostaglandin synthase inhibitors sangathe kuletsa bwino kutsekeka kwa uterine.
Zotsatira
Atosiban ndi ophatikizika amalandila oxytocin ndi vasopressin V1A, kapangidwe kake ka mankhwala ndi kofanana ndi ziwirizo, ndipo imakhala ndi kuyanjana kwakukulu kwa zolandilira, ndipo imapikisana ndi oxytocin ndi vasopressin V1A receptors, potero imatsekereza njira ya oxytocin ndi vasopressin ndikuchepetsa kutsekeka kwa uterine.
