Atoshiban acetate omwe amagwiritsidwa ntchito pobereka asanabadwe
Tsatanetsatane wazogulitsa
| Dzina | Atosiban |
| Nambala ya cas | 90779-69-4 |
| Mawonekedwe a matope | C43h67N11o12S2 |
| Kulemera kwa maselo | 994.19 |
| Nambala ya Einecs | 806-815-5 |
| Malo otentha | 1469.0 ± 65.0 ° C (Extrated) |
| Kukula | 1.254 ± 0.06 g / cm3 (kulosera) |
| Malo osungira | -20 ° C |
| Kusalola | H2O: ≤100 mg / ml |
Kaonekeswe
ATosiban Acetate ndi ogwirizanitsa polypeptide okhala ndi 9 amino acid. Ndiosasintha molecurin m'malo 1, 2, 4 ndi 8. [D-tyr (et) 2, ndi Atoshiban acetate imagwiritsidwa ntchito mu mankhwala monga viniga zimapezeka mu mawonekedwe a acid, omwe amadziwika kuti aceosiban acetate.
Karata yanchito
Atosiban ndi oxytocin ndi vasopresten v1a kuphatikiza wonamizira, wolandila wa axytocin amafanana ndi vasopressel v1a receptor. Pamene oxytocin recepptor atsekedwa, oxytocin amathanso kuchita kudzera mu v1a receptor, motero ndikofunikira kutseka njira ziwiri zolandirira nthawi yomweyo, ndipo malingaliro amodzimodzi a receptor imodzi imatha kuyika mwamphamvu kuphwanya chiberekero. Iyi ndi imodzi mwazifukwa zazikulu zomwe zimapangitsa agonistist agonists, calcium Channel blockers ndi prostaglandin synthase inhibitors mosabisa sizingabisire zosemphana ndi chiberekero.
Kukhudza
Atosiban ndi wotsutsana ndi wolandila wa oxytocin ndi vasopressin v1a, kapangidwe kake kamakhala wofanana ndi ziwirizo, ndipo ali ndi mafinya ovomerezeka a oxytocin ndi vasopresten ndi kuchepetsa zophatikiza ndi uterine.
