Vvarnafil dihhydrochloride kuchitira erectule dysfunaction 224785-91-5

Zochita za pharmacological
Mankhwala ndi a phosphodesteanthulat mtundu 5 (pde5) inrobitor. Kupanga pakamwa kwa mankhwalawa kumatha kusintha mtunduwo komanso nthawi yayitali, ndikusintha bwino kwa moyo wachiwerewere mwa odwala amuna omwe ali ndi erectile. Kuyambitsa ndi kukonza kwa ma penile kumakhudzana ndi kupumula kwa candoshusy yosalala ceposphate (CGMPM) ndi mkhalapakati wa kupumula kwa canle shuga maselo osasamba. Mankhwalawa amalepheretsa kuwonongeka kwa CGMP poletsa mtundu wa phosphodesteanthulaptop mtundu 5, potero ndikupangitsa kudzikundikira kwa CGMP, kupumula kosalala kwa minofu ya Corpus Caverus Cavertu, ndi mawonekedwe a mbolo. Poyerekeza ndi phosphodequeset ausozyme 1, 2, 3, 4, 4, ndipo mankhwalawa ali ndi kusamwa kwambiri kwa mtundu wa 5 phosphodesies. Zambiri zimawonetsa kuti kusankha kwake ndi kusinthika kwa mphamvu pa phosphodesteiestiesteanthusteft mtundu 5 ndibwino kuposa mtundu wina wa phosphodesteanthur. Mtundu wa phosphodiestoat inhibittors ndi ochepa.

Mankhwala othandizira ndi mapulogalamu

1. Kusintha kowoneka, kupweteka mutu, nkhope zotuluka, prianplism). Mankhwala ayenera kupewa kuphatikiza ndi ritonavir ndi indinavir. Akagwiritsidwa ntchito limodzi ndi erythromycin, a Cloconazole, ndi itracnazoro, mlingo waukulu wa mankhwalawa sayenera kupitirira 5 mg, ndipo mlingo wa ketoconazole ndi Itracnazole sayenera kupitirira 200 mg.
2. Odwala amatenga ma nitrate kapena kulandira Nitric Ondor chithandizo chokwanira ayenera kupewa kugwiritsa ntchito mankhwalawa. Makina ake achitapo kanthu kuti awonjezereKukhazikika kwa CGMP, zomwe zimapangitsa antihypertensive zotsatira komanso kuchuluka kwa mtima. Tikamagwiritsidwa ntchito limodzi ndi blocker oledzera, imatha kukulitsa mphamvu ya antihypertensive ndikuyambitsa hypotension. Chifukwa chake, kugwiritsa ntchito mankhwalawa kumaletsedwa kwa iwo omwe akugwiritsa ntchito ma blockers. Zakudya zamafuta apakatikati (30% ya zopatsa mphamvu zamafuta) zidalibe mphamvu pa pharmacokinetics mlingo umodzi wa 205% ya mankhwalawa a mankhwalawa ndi pafupifupi 18%.

Pharmacokinetics
Amakhala omwa mofulumira pambuyo pokhazikitsidwa pakamwa, mtundu wa bioavailability wa piritsi ndi 15%, ndipo nthawi yayitali ku Peak ndi 1h (0,5-2h). Pakamwa CHOYAMBA 10MG kapena nthawi yayitali kwambiri ndi 0.9h ndi 0μg / l ndi 21μg / l, motero, komanso nthawi ya mankhwala osokoneza bongo atha kufikira 1h. Mankhwala omanga mapuloteni amafunika pafupifupi 95%. 1.5h atatha mlingo wamlomo wa 20 mg, zomwe zimapezeka mu umuna ndi 0.00018% ya mlingo. Mankhwalawa amapangidwa makamaka mu chiwindi ndi cytochrome p450 (cyp) 3A4, ndipo ndalama zochepa zimapangidwa ndi cyp 3a5 ndi cyp 2C9 isoenzymes. Mkati mwa metabolite ndi m1 yopangidwa ndi kutsuka kwa kusakhazikika kwa mankhwalawa. M1 ilinso ndi zotsatira zoletsa phosphodesteanthulat facfodiesteanthula ka 5 (pafupifupi 7% ya chiwerengero chonse), ndipo magazi ake ndende ndi pomwe 26% ya magazi a kholo. , ndipo zitha kuphatikizidwa. Mitengo ya mankhwala osokoneza bongo mu mawonekedwe a metabolites mu ndowe ndi mkodzo ndi pafupifupi 91% mpaka 95% ndi 2% mpaka 6%, motsatana. Chiwerengero chonsecho ndi 56 l pa ola limodzi, ndipo theka la moyo wa kholo ndi m1 onse ali pafupifupi maola 4 mpaka 5.