Tianeptine sodium ya Episses

Kugwiritsa ntchito

Zimachitika makamaka pa dongosolo la 5-HT, popanda chisangalalo, sedation, anti-acetycholine ndi mtima. Chifukwa cha nkhawa.

Pharmacological zotsatira

1. Makina antidepressant a malonda awa ndi osiyana ndi a TCA yachikhalidwe. Zimatha kuwonjezera patali ndi 5-ht mu synaptic cleft, koma imafota kwambiri pakubwezeretsanso 5-ht ndi na. Atha kukhala ndi zotsatira zowonjezera kufalikira kwa 5-HT neuronal. Ilibe ubale chifukwa cha olandila, H1, í1 ndi í1 ndi í1-na receptors.
2. Chithandizo cha antidepreschent cha mankhwalawa ndi ofanana ndi tca, ndipo kutetezedwa ndi kulolera kwake kuli bwino kuposa tca (tricyclic antidepressants). Chotheka pazinthu izi ndizofanana ndi za SSri Fluoxetine.
3. Kuyesedwa kwa mankhwala a nyama kwawonetsa kuti zitha: Kuchulukitsa zochitika za ma piramidi mu hippocampus ndikuwonjezera kuchira kwa ntchito yake pambuyo pa ntchito yake. Onjezani rebsorption ya 5-hydroxtryptine ndi ma neuron mu cellul cortex ndi hippocampus.

Maphunziro a toxicology

- pachimake, kuperewera kwadzidzidzi ndi kwa nthawi yayitali: Palibe kusintha kwa sayansi, kugwiritsidwa ntchito kwa chiwindi, matendawa.
- Kuletsa kwa teracticity ndi mayeso a teratogenicity: Tianeptine alibe mphamvu kukhoza kwa makolo omwe ali ndi zaka fetus ndi ana.
- Kuyesa kwa Mutagenic: Tianeptine alibe Mutagenic zotsatira.