Tadalafil 171596-29-5 kuti mukwaniritse nkhani zakukhosi mwa amuna

Tadalafil (Tadalafil, Tadalafil) ali ndi mawonekedwe a c22h19n3o4 ndi mawonekedwe a kulemera kwa 389.4. Zagwiritsidwa ntchito kwambiri pochiza matenda a matenda a matenda achimuna kuyambira 2003, ndi dzina la malonda cialis (cialis). Mu June 2009, FDA yovomerezeka ku United States pochiza odwala omwe ali ndi matenda a m'mapapo matenda oopsa a ADCRA. TadAlafil adayambitsidwa mu 2003 ngati mankhwala othandizira Ed. Zimatengera kukonzekera mphindi 30 pambuyo pokonza, koma zotsatira zake zabwino ndi 2h mutatha chochitika, ndipo zotsatira zake zitha kukhala 36h, ndipo zotsatira zake sizikhudzidwa ndi chakudya. Mlingo wa Tadalafil ndi 10 kapena 20 mg, mlingo woyenera woyamba ndi 10 mg, ndipo mlingo umasinthidwa mogwirizana mogwirizana ndi zomwe wodwalayo akuchita komanso zovuta zina. Kafukufuku wa Msika Awo adawonetsa kuti pambuyo pokhazikitsa pakamwa pa 10 kapena 20 mg ya tadafil kwa milungu 12, mitengo yothandiza ndi 67%, motsatana. Kafukufuku ambiri awonetsa kuti Tadalafil ali bwino kwambiri pazomwe Ed.

Erectile Dysfunction: Tadalafil ndi njira yosankha phosphodestesenthula yopanda tanthauzo, koma kapangidwe kake ndizosiyana ndi zomaliza, komanso zakudya zochuluka sizisokoneza kuyamwa. Mothandizidwa ndi zogonana, nitric synthase (nos) mumalekezero amitsempha ndi ma centlial endothelis and cellhels and arlic oxide (ayi) kuchokera ku L-Arkinine. Palibe amene akuyambitsa guanylat Cyclase, yomwe imatembenuza Guanosine ku cintenasine monopthosphate-ma cinaleosum erectiotion imachitika chifukwa cha minofu yosalala. Phosphodesteanthulap mtundu 5 (pde5) amasagwira ntchito mwa zinthu zophera, ndikupanga mbolo kukhala yofooka. Tadalafil amalepheretsa kuwonongeka kwa pade5, kumapangitsa kuti chidziwe cha CGMP, chomwe chimapuma minofu yosalala ya Corpus Cavertundu Popeza ma nitrate sapereka opereka, kuphatikiza ndi Tadalafil kumawonjezera kuchuluka kwa CGMP ndikumatsogolera ku hypotension. Chifukwa chake, kuphatikiza kwa awiriwo kumapangidwa muchipatala.

Tadalafil amagwira ntchito poletsa ma pdes. GMP imawonongeka, kugwiritsa ntchito ma nitrates kungayambitse kuponderezedwa kwambiri m'magazi ndikuwonjezera chiopsezo cha syncope. CY3PA4 inducers will reduce the bioavailability of tadanafil, and the combination with rifampicin, cimetidine, erythromycin, clarithromycin, itracon, ketocon, and HVI protease inhibitors may increase the The blood concentration of the drug should be adjusted. Pakadali pano, palibe maumboni omwe pharmacokinetic magawo a malonda awa amakhudzidwa ndi zakudya ndi mowa.