Tadalafil 171596-29-5 Kuchiza Erectile Dysfunction mwa Amuna

Tadalafil (Tadalafil, Tadalafil) ili ndi ndondomeko ya molekyulu ya C22H19N3O4 ndi kulemera kwa 389.4. Amagwiritsidwa ntchito kwambiri pochiza vuto lachimuna la erectile kuyambira 2003, ndi dzina lamalonda la Cialis (Cialis). Mu June 2009, a FDA adavomereza tadalafil ku United States kuti azichiritsira odwala omwe ali ndi pulmonary arterial hypertension (PAH) pansi pa dzina la malonda Adcirca. Tadalafil idayambitsidwa mu 2003 ngati mankhwala ochizira ED. Zimatengera mphindi 30 pambuyo pa makonzedwe, koma zotsatira zake zabwino ndi 2h pambuyo poyambira, ndipo zotsatira zake zimatha kwa 36h, ndipo zotsatira zake sizimakhudzidwa ndi chakudya. Mlingo wa tadalafil ndi 10 kapena 20 mg, mlingo woyambirira wovomerezeka ndi 10 mg, ndipo mlingo umasinthidwa malinga ndi momwe wodwalayo akuyankhira ndi zotsatira zake zoipa. Kafukufuku wamsika wasonyeza kuti pambuyo poyendetsa pakamwa pa 10 kapena 20 mg ya tadalafil kwa masabata a 12, mitengo yogwira ntchito ndi 67% ndi 81%, motero. Kafukufuku wambiri wasonyeza kuti tadalafil imakhala yothandiza kwambiri pochiza ED.

Erectile Dysfunction: Tadalafil ndi mtundu wosankha wa phosphodiesterase 5 (PDE5) monga sildenafil, koma kapangidwe kake ndi kosiyana ndi kotsiriza, ndipo zakudya zamafuta kwambiri sizimasokoneza kuyamwa kwake. Pansi pa zokondoweza za kugonana, nitric oxide synthase (NOS) m'mitsempha ya mbolo ndi ma cell endothelial cell catalyzes kaphatikizidwe ka nitric oxide (NO) kuchokera ku gawo lapansi L-arginine. NO imayendetsa guanylate cyclase, yomwe imatembenuza guanosine triphosphate kukhala cyclic guanosine monophosphate (cGMP), potero imayendetsa cyclic guanosine monophosphate-amadalira protein kinase, zomwe zimapangitsa kuchepa kwa ayoni a calcium m'maselo osalala a minofu, kuchititsa kuti corpus cavernosum Erection ichitike chifukwa cha kupumula kwa minofu yosalala. Phosphodiesterase type 5 (PDE5) imasokoneza cGMP kukhala zinthu zosagwira ntchito, kupangitsa mbolo kukhala yofooka. Tadalafil imalepheretsa kuwonongeka kwa PDE5, zomwe zimapangitsa kuti cGMP iwonongeke, yomwe imatulutsa minofu yosalala ya corpus cavernosum, yomwe imatsogolera ku penile erection. Popeza kuti ma nitrate ndi NO opereka, kugwiritsa ntchito pamodzi ndi tadalafil kudzawonjezera kwambiri mlingo wa cGMP ndikuyambitsa kutsika kwa magazi. Choncho, kugwiritsidwa ntchito pamodzi kwa awiriwa kumatsutsana ndi zochitika zachipatala.

Tadalafil imagwira ntchito poletsa PDES. GMP imawonongeka, kotero kugwiritsidwa ntchito pamodzi ndi nitrates kungayambitse kutsika kwakukulu kwa kuthamanga kwa magazi ndikuwonjezera chiopsezo cha syncope. CY3PA4 inducers amachepetsa bioavailability wa tadanafil, ndipo kuphatikiza rifampicin, cimetidine, erythromycin, clarithromycin, itracon, ketocon, ndi HVI protease inhibitors kuonjezera kuchuluka kwa magazi a mankhwalawa kuyenera kusinthidwa. Mpaka pano, palibe malipoti oti magawo a pharmacokinetic a mankhwalawa amakhudzidwa ndi zakudya ndi mowa.