Sildenafil Citrate Kuchiza Erectile Dysfunction 171599-83-0
Tsatanetsatane wa Zamalonda
| Dzina | Sildenafil citrate |
| Nambala ya CAS | 171599-83-0 |
| Molecular formula | Chithunzi cha C28H38N6O11S |
| Kulemera kwa maselo | 666.70 |
| Nambala ya EINECS | 200-659-6 |
| Merck | 14,8489 |
| Kuchulukana | 1.445g/cm3 |
| Mkhalidwe wosungira | 2-8 ° C |
| Fomu | Ufa |
| Mtundu | Choyera |
| Kusungunuka kwamadzi | DMSO:> 20mg/mL |
Mawu ofanana ndi mawu
Viagra, Sildenafil citrate; 1- [[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl] -4-methylpiperazinecitratesalt; 5- [2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e]pyrimidin-7-onecitratesalt; 1- [[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate (100mg); Sildenafilcitrate,> = 99%;Sildenafilcitrate,Akatswiri ogulitsa; 5- [2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Pharmacological Effect
Pharmacological Action
Sildenafil citrate ndi yosankha 5-phosphodiesterase inhibitor yomwe imapangitsa kuti nitric oxide-dependent, cyclic guanosine monophosphate-mediated pulmonary vasodilation ikulepheretse kuwonongeka kwa cyclic guanosine monophosphate. Kuphatikiza pa kufalikira kwachindunji kwa mitsempha ya m'mapapo, kungathenso kulepheretsa kapena kusintha kusintha kwa mitsempha.
Katundu Wamankhwala ndi Ntchito
Sildenafil citrate, dzina la malonda Viagre, lomwe limadziwika kuti Viagra, ndi cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5) inhibitor yomwe ingapangitse erection pambuyo poyendetsa pakamwa. Sildenafil citrate ikhoza kupititsa patsogolo mphamvu ya nitric oxide (NO) mwa kuletsa mtundu wa 5 phosphodiesterase umene umatulutsa cyclic guanosine monophosphate (cGMP) mu corpus cavernosum. Wonjezerani kuchuluka kwa cGMP mu corpus cavernosum, kumasula minofu yosalala mu corpus cavernosum, kuonjezera kutuluka kwa magazi, kutalikitsa nthawi yomanga mbolo ndikuwonjezera kulimba. Kwa odwala omwe ali ndi vuto la erectile dysfunction. Akuluakulu amatenga 50 mg pakamwa nthawi iliyonse, mpaka 1 nthawi patsiku, ndipo agwiritseni ntchito pakufunika pafupifupi ola la 1 musanayambe kugonana. Kuchuluka kwakukulu ndi 0.1g nthawi iliyonse.
Maphunziro mu vivo
Mu agalu osowa magazi, Sildenafil citrate imapangitsa kuti penile erectile igwire ntchito pansi pa kukondoweza kwa mitsempha ya m'chiuno poyesa kuthamanga kwa intracavernous. Sildenafil citrate adasinthiratu kupumula kwa carbamoylcholine komanso kulepheretsa mapangidwe a superoxide mu minofu ya cavernosal ya akalulu a hypercholesterolemic. Mu makoswe a Sprague-Dawley, Sildenafil imapangitsa kuti erectile igwire ntchito motsatira mlingo wa nthawi, ndipo kuchira kwakukulu kumachitika tsiku la 28 pa mlingo wa 20 mg / kg patsiku. Mu makoswe a Sprague-Dawley, kayendetsedwe ka Sildenafil kunapangitsa kuti minofu ya collagen ikhale yosalala komanso kusunga CD31 ndi eNOS mawu. Mu makoswe a Sprague-Dawley, Sildenafil anachepetsa kwambiri chiwerengero cha apoptotic ndikuwonjezera phosphorylation ya akt ndi eNOS poyerekeza ndi gulu lolamulira.
