Rapmycin ndi mankhwala a immunosuppressive, anti-khansa ndi anting-ukalamba

Kaonekeswe

Rapmycin ndi mankhwala a macride omwe amafanana ndi profofol (fk506), koma ali ndi njira yosiyana kwambiri. FK506 imalepheretsa kuchuluka kwa tz lymphocytes kuchokera ku g0 gawo la gytokine ndi ma cell a c102 Ofufuza aku Chicago amagwiritsa ntchito mapiritsi a ramycin pakamwa kuphatikiza madzi a mphesa kuti azichita masewera olimbitsa thupi, omwe angathandizenso kuwononga mankhwala a chemotherey nthawi yayitali. Kafukufuku wasonyeza kuti rammycin amapulumutsidwa mosavuta ndi michere yam'mimba, ndipo madzi a mphesa amakhala ndi makoma ambiri, omwe amatha kuletsa mphamvu zowonongeka za michere ya Rapimpycin. Imatha kusintha bioavailability wa Rapycin. Amati madokotala akale kwambiri azindikira kuti madzi a mphesa ali ndi tanthauzo la kuyanjana ndi kusintha kwapakamwambo kwa King Hang, ndipo tsopano madokotala ku mayiko aku Europe ndi America agwiritsa ntchito ku Rampycin Kukonzekera kwa Rapemycin.

M'zaka zaposachedwa, maphunziro awona kuti chandamale cha Rapemycin (MTSOGOLO) ndi Minase, komanso vuto la cormce yolumikizana zitha kuchititsa matenda osiyanasiyana. Monga choletsa choletsa ku MTT, Rapimycin amatha kuchiza zotupa kwambiri ndi njira iyi, kuphatikiza khansa ya lymmphoma, khansa ya chiwindi, khansa ya neroroendochine. Makamaka mankhwalawa matenda awiri osowa, lam (lymphangiomyomotonomos) ndi tcharous sclerosis), zotsatirazi zikuwonekeratu, ndipo ma lam ndi TSC iwonedwenso ngati matenda otupa pamlingo wina.

Zotsatira zoyipa

Rapycin (Rapa) amakhala ndi zotsatirazi zofananira ndi fk506. M'mayesero ambiri azachipatala, zotsatira zake zidapezeka kuti ndi mlingo wodalirika komanso wosinthika, ndipo Rapa pa achire Mlingo sanapezeke kukhala ndi nephrotoxicity yofunika kwambiri ndipo palibe gingivalplasia. Zotsatira zazikulu zowopsa komanso zoyipa zimaphatikizapo: mutu, nseru, chizungulire, mphuno, komanso zopweteka. Zovuta za labortory zimaphatikizapo: thrombocytopenia, leukopenia, herpercrigon, hypergullycemide, hyperglyceremia, ellid edema idanenedwa posachedwa Ndi Rapa Administration, ndipo chifukwa cha kuchuluka kwa ma plasma phosphate phoslate. Monga ena a sammunosupressants, Rapa ali ndi mwayi wolemera, wokhala ndi chizolowezi chowonjezereka kuti aletse chibayo makamaka, koma kupezeka kwina kopanda tanthauzo sikusiyana kwambiri ndi CSA.