Zosakaniza za Pharma
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Fmoc-Ls(Pal-Glu-OtBu)-OH
Fmoc-Ls(Pal-Glu-OtBu) -OH ndi chipika chapadera cha amino acid chomangira chopangira peptide-lipid conjugation. Imakhala ndi lysine yotetezedwa ndi Fmoc yokhala ndi unyolo wam'mbali wa palmitoyl-glutamate, kukulitsa kuyanjana kwa membrane ndi bioavailability.
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Fmoc-His-Aib-OH
Fmoc-His-Aib-OH ndi chomangira cha dipeptide chomwe chimagwiritsidwa ntchito popanga peptide, kuphatikiza Fmoc-protected histidine ndi Aib (α-aminoisobutyric acid). Aib imayambitsa kukhazikika kwa conformational, ndikupangitsa kuti ikhale yofunikira popanga ma helical ndi okhazikika ma peptides.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH ndi chidutswa chotetezedwa cha tetrapeptide chomwe chimagwiritsidwa ntchito popanga peptide ndi chitukuko cha mankhwala. Lili ndi magulu ogwira ntchito otetezedwa mwanzeru kuti agwirizane pang'onopang'ono komanso amakhala ndi Aib (α-aminoisobutyric acid) kuti apititse patsogolo kukhazikika kwa helix ndi kukhazikika kogwirizana.
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU ndi molekyulu yopangira lipidated yolumikizira yomwe idapangidwira kuti iperekedwe ndi mankhwala omwe amalimbana ndi antibody-drug conjugates (ADCs). Imakhala ndi mchira wa stearoyl (Ste) hydrophobic, γ-glutamyl yolunjika, AEEA spacers for flexibility, ndi gulu la OSu (NHS ester) lolumikizana bwino.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH ndi chomangira chotetezedwa cha tripeptide chokhala ndi α-methylated leucine, chomwe chimagwiritsidwa ntchito popanga mankhwala a peptide kuti apititse patsogolo kukhazikika kwa kagayidwe kachakudya komanso kusankha kolandirira.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) ndi chotsukira chopangira zwitterionic chomwe chimagwiritsidwa ntchito kwambiri pofufuza za protein ya membrane ndi biology yamapangidwe, makamaka mu NMR spectroscopy ndi crystallography.
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Donilorsen
Donilorsen API ndi antisense oligonucleotide (ASO) yomwe ikufufuzidwa pochiza angioedema ya cholowa (HAE) ndi zina zotupa. Amaphunziridwa mu nkhani ya RNA-zochizira, cholinga kuchepetsa kufotokozaplasma prekallikrein(KLKB1 mRNA). Ofufuza amagwiritsa ntchito Donidalorsen kuti afufuze njira zochepetsera ma jini, ma pharmacokinetics omwe amadalira mlingo, komanso kuwongolera kwanthawi yayitali kwa kutupa kwa bradykinin.
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Fitusiran
Fitusiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) komwe kumafufuzidwa makamaka pankhani ya hemophilia ndi matenda a coagulation. Imalimbana ndiantithrombin (AT kapena SEPINC1)jini m'chiwindi kuti achepetse kupanga kwa antithrombin. Ofufuza amagwiritsa ntchito Fitusiran kuti afufuze njira za RNA interference (RNAi), kuletsa jini yeniyeni ya chiwindi, ndi njira zatsopano zochiritsira zochepetsera coagulation mu hemophilia A ndi B odwala, kapena opanda zoletsa.
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Givosiran
Givosiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) yophunzirira pochiza pachimake kwa chiwindi porphyria (AHP). Imalimbana makamaka ndiALAS1jini (aminolevulinic acid synthase 1), yomwe imakhudzidwa ndi njira ya heme biosynthesis. Ofufuza amagwiritsa ntchito Givosiran kuti afufuze njira zochiritsira za RNA interference (RNAi), kuletsa jini yolimbana ndi chiwindi, komanso kusintha kwa kagayidwe kachakudya kamene kamayambitsa porphyria ndi matenda okhudzana ndi majini.
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Plozasiran
Plozasiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) komwe kamapangidwira kuchiza hypertriglyceridemia ndi matenda okhudzana ndi mtima ndi kagayidwe kachakudya. Imalimbana ndiAPOC3jini, yomwe imayika apolipoprotein C-III, wowongolera kwambiri wa triglyceride metabolism. Pofufuza, Plozasiran amagwiritsidwa ntchito pophunzira njira zochepetsera lipids za RNAi, gene-sencing specificity, ndi mankhwala okhalitsa kwa nthawi yaitali monga matenda a chylomicronemia syndrome (FCS) ndi dyslipidemia yosakanikirana.
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Zilebesiran
Zilebesiran API ndi kafukufuku waung'ono wosokoneza RNA (siRNA) wopangidwa kuti azichiza matenda oopsa. Imalimbana ndiAGTjini, yomwe imayika angiotensinogen - chigawo chachikulu cha renin-angiotensin-aldosterone system (RAAS). Pofufuza, Zilebesiran amagwiritsidwa ntchito pophunzira njira zochepetsera ma jini pakuwongolera kuthamanga kwa magazi kwa nthawi yayitali, matekinoloje operekera RNAi, komanso gawo lalikulu la njira ya RAAS pamtima ndi aimpso.
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Caspofungin kwa Matenda a Antifungal
Dzina: Caspofungin
Nambala ya CAS: 162808-62-0
Molecular formula: C52H88N10O15
Kulemera kwa molekyulu: 1093.31
Nambala ya EINECS: 1806241-263-5
Malo otentha: 1408.1±65.0 °C (Zonenedweratu)
Kachulukidwe: 1.36±0.1 g/cm3(Zonenedweratu)
Acidity coefficient: (pKa) 9.86±0.26 (Zonenedweratu)