Orlistat 96829-58-2 Kuchepetsa Mayamwidwe a Sietary Mafuta, Kumabweretsa Kuwonda

Katundu

White crystalline ufa, pafupifupi osasungunuka m'madzi, osungunuka mosavuta mu chloroform, osungunuka kwambiri mu methanol ndi ethanol, osavuta kupukuta, malo osungunuka ndi 40 ℃～42 ℃. Molekyu yake ndi diastereomer yomwe ili ndi malo anayi a chiral, pamtunda wa 529nm, yankho lake la ethanol limakhala ndi kasinthasintha kosokoneza.

Kachitidwe

Orlistat ndi m'mimba ya lipase inhibitor yomwe imakhala nthawi yayitali komanso yamphamvu, yomwe imayambitsa ma enzyme awiri omwe ali pamwambawa popanga mgwirizano wogwirizana ndi malo okhudzidwa a serine a lipase m'mimba ndi m'matumbo aang'ono. Ma enzyme osagwiritsidwa ntchito sangathe kuphwanya mafuta muzakudya kukhala mafuta aulere acids ndi Chemicalbook glycerol yomwe imatha kuyamwa ndi thupi, potero amachepetsa kudya kwamafuta ndikuchepetsa kulemera. Kuphatikiza apo, kafukufuku wina wapeza kuti orlistat imalepheretsa kuyamwa kwa cholesterol m'matumbo mwa kuletsa niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Zizindikiro

Izi mankhwala osakaniza ndi wofatsa hypocaloric zakudya zikusonyeza kwa nthawi yaitali mankhwala a anthu onenepa ndi onenepa kwambiri, kuphatikizapo amene anakhazikitsa chiopsezo zinthu zogwirizana ndi kunenepa kwambiri. Mankhwalawa ali ndi nthawi yayitali yoletsa kulemera kwa thupi (kuwonda, kukonza kulemera ndi kupewa kubwezera) mphamvu. Kutenga orlistat kumatha kuchepetsa ziwopsezo zokhudzana ndi kunenepa kwambiri komanso kuchuluka kwa matenda ena okhudzana ndi kunenepa kwambiri, kuphatikiza hypercholesterolemia, matenda a shuga a 2, kulolerana kwa shuga, hyperinsulinemia, matenda oopsa, komanso kuchepetsa mafuta m'thupi.

Kuyanjana kwa Mankhwala

Ikhoza kuchepetsa kuyamwa kwa mavitamini A, D ndi E. Ikhoza kuwonjezeredwa ndi mankhwalawa panthawi imodzi. Ngati mukukonzekera zokhala ndi mavitamini A, D ndi E (monga ma multivitamini), muyenera kumwa mankhwalawa 2 hours mutatha kumwa mankhwalawa kapena pogona. Anthu omwe ali ndi matenda amtundu wa 2 angafunikire kuchepetsa mlingo wamankhwala amkamwa a hypoglycemic (mwachitsanzo, sulfonylureas). Kugwiritsa ntchito limodzi ndi cyclosporine kungayambitse kuchepa kwa kuchuluka kwa plasma komaliza. Kugwiritsa ntchito munthawi yomweyo amiodarone kungayambitse kuchepa kwa kuyamwa komaliza ndikuchepetsa mphamvu.