Orlistat 96829-58-58-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-25-250 mafuta a mafuta, zomwe zimapangitsa kunenepa
Tsatanetsatane wazogulitsa
| Dzina | Orlistat |
| Nambala ya cas | 96829-58-25-25-25-2 |
| Mawonekedwe a matope | C29h53N5 |
| Kulemera kwa maselo | 495.73 |
| Nambala ya Einecs | 639-755-1 |
| Malo osungunuka | <50 ° C |
| Kukula | 0.976 ± 0.06G / CM3 (OKHULUPIRIRA) |
| Kusunga | 2-8 ° C |
| Fumu | Pawuda |
| Mtundu | Oyera |
| Acidity zolimba | (PKA) 14.59 ± 0,23 (kulosera) |
Mawuno
(S) -2-formylamino-4-methyl-pentanoicacid (s) -1 - [[2s, 3s)-4-axehhydyl; Ormyl-L-Leucine (1s) -1 - [2s, 3s) -3-Hexyl-4-Oxet (Sylistat (Sylistat (Scamesis)
Pharmacological zotsatira
Katundu
Madzi oyera oyera, pafupifupi insuluble m'madzi, osungunuka mosavuta mu chloroform, solble kwambiri ku methanol ndi Ethanol, zosavuta ku Pyrolyze, malo osungunuka ndi 40 ~ 42 ℃. Molekyu yake ndi diapereame yokhala ndi makiriti anayi, pamalo owopsa a 529nm, ethanol yake imakhala yosasokoneza.
Njira Yochita
Orlistat ndi miyala yamtengo wapatali yosangalatsa komanso yamphamvu yolowera m'mimba, yomwe imalumikizana ndi ma enzyme awiri omwe ali pamwambawa popanga zogwirizana ndi Covalent ndi malo ogwiritsiridwa ndi mitengo yamimba ndi matumbo ang'onoang'ono. Ma enzymes osavomerezeka sangathe kuwononga mafuta mu chakudya chamafuta acids acid ndi mankhwala ena amatha kulowetsedwa ndi thupi, potero amachepetsa kudya komanso kuchepetsa thupi. Kuphatikiza apo, maphunziro ena awona kuti orlistat amalepheretsa matumbo a cholesterol poletsa Niemann-cofting 1 (NPC1L1).
Umboni
Izi kuphatikiza ndi zakudya zofatsa za hypocaloric zofatsa zimawonetsedwa kuti zikuthandizira anthu onenepa kwambiri komanso onenepa, kuphatikizapo omwe ali ndi ziwopsezo zomwe zimachitika chifukwa cha kunenepa kwambiri. Izi zimakhala ndi mphamvu yayitali yolemera (kuchepa thupi, kukonza thupi komanso kupewa kubwezeretsanso). Kutenga orlistat kumatha kuchepetsa mavuto onenepa kwambiri komanso matenda ena ofananira ndi matenda ena ofananira, kuphatikizapo hypercholesterolemia, kulolerana kwa shuga 2, hypenizerelinemia, matenda oopsa, ndipo gawo lochepetsa mafuta.
Zogwirizana
Imatha kuchepetsa kuyamwa kwa mavitamini A, D ndi E. Itha kuperekedwa ndi izi nthawi yomweyo. Ngati mukukonzekera kukhala ndi mavitamini A, D ndi E (monga mathithinins ena), muyenera kutenga izi maola awiri mutangotenga izi kapena nthawi yogona. Anthu omwe ali ndi matenda a shuga 2 angafunike kuchepetsa mlingo wa othandizira am`kamwa (mwachitsanzo, sulfonylureas). Co-malemu ndi cyclosporine imatha kuchepa kwa kuchuluka kwa plasma yotsiriza. Kugwiritsa ntchito Amiodarone kumatha kutsika kuyamwa kwakumapeto kwake ndikuchepetsa mphamvu.
