MOTS-C

Kufotokozera Kwachidule:

MOTS-C API imapangidwa pansi pamikhalidwe yolimba ngati ya GMP pogwiritsa ntchito ukadaulo wa solid phase peptide synthesis (SPPS) kuti iwonetsetse kuti imakhala yapamwamba kwambiri, yoyera kwambiri komanso yokhazikika pakufufuza komanso kugwiritsa ntchito mankhwala.
Zogulitsa:

Kuyera ≥ 99% (kutsimikiziridwa ndi HPLC ndi LC-MS),
Endotoxin yotsika komanso zosungunulira zotsalira,
Zopangidwa molingana ndi ma protocol a ICH Q7 ndi GMP,
Itha kukwaniritsa kupanga kwakukulu, kuchokera pamagulu a R&D a milligram-level mpaka gram-level ndi malonda a kilogalamu.

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogulitsa Tags

MOTS-C API

MOTS-C(Mitochondrial Open Reading Frame ya 12S rRNA Type-c) ndi 16-amino acid.peptide yochokera ku mitochondria (MDP)kusinthidwa ndi mitochondrial genome. Mosiyana ndi ma peptide achikhalidwe okhala ndi nyukiliya, MOTS-c imachokera ku 12S rRNA dera la mitochondrial DNA ndipo imagwira ntchito yofunika kwambirikuwongolera kagayidwe ka cellular, kuyankha kupsinjika, komanso kumva kwa insulin.

Monga peptide yatsopano yochizira,MOTS-c APIwapeza chidwi kwambiri m'magawo amatenda a metabolic, ukalamba, physiology yolimbitsa thupi, ndi mankhwala a mitochondrial. Peptide pakadali pano ikufufuzidwa mozama ndipo imadziwika kuti ndi yodalirikam'badwo wotsatira wa peptide therapeuticskutsata thanzi la metabolic komanso moyo wautali.

Njira Yochitira

MOTS-c imakhala ndi zotsatira zake kudzeramitochondrial-nuclear cross-talk-njira yomwe mitochondria imalumikizana ndi nyukiliya kuti isunge ma cell homeostasis. Peptide imasamutsidwa kuchokera ku mitochondria kupita ku nyukiliya chifukwa cha kupsinjika kwa metabolic, komwe imakhalametabolic regulatorpotengera geni.

Njira zazikuluzikulu zachilengedwe zimaphatikiza:

Kuyambitsa kwa AMPK (AMP-activated protein kinase):MOTS-c imapangitsa AMPK, mphamvu yapakati, yolimbikitsakutengeka kwa glucose, mafuta acid oxidation, ndi mitochondrial biogenesis.
Kuwonjezeka kwa insulin sensitivity:MOTS-c imawonjezera kuyankha kwa insulin mu minofu ndi minofu ya adipose, ndikuwongoleraglucose homeostasis.
Kuchepetsa kupsinjika kwa okosijeni ndi kutupa:Mwa kusintha ma cell redox moyenera komanso njira zowonetsera zotupa.
Kuwongolera ntchito ya mitochondrial ndi biogenesis:Imathandizira thanzi la mitochondrial, makamaka pansi pa kupsinjika kapena kukalamba.

Kafukufuku Wamankhwala ndi Zachilengedwe Zachilengedwe

Maphunziro a preclinical awonetsa zotsatira zambiri zakuthupi ndi zamankhwala za MOTS-c mumitundu yonse ya mu vitro ndi nyama:

1. Matenda a Metabolic (Kunenepa Kwambiri, Type 2 Diabetes, Insulin Resistance)

Imawongolera kulolerana kwa glucose ndikuchepetsa kuchuluka kwa shuga m'magazi
Zimawonjezerainsulin sensitivitypopanda kuwonjezeka kwa insulin
Imalimbikitsakuwonda ndi oxidation mafutamu mbewa onenepa kwambiri chifukwa cha zakudya

2. Anti-Kukalamba ndi Moyo Wautali

Miyezo ya MOTS-c imatsika ndi zaka, ndipo zowonjezera mu mbewa zokalamba zasonyezedwakuonjezera mphamvu za thupi, onjezerani ntchito ya mitochondrial,ndikuchedwa kuchepa kwa zaka.
Kupititsa patsogolo ntchito zolimbitsa thupi komansokupirira kwa minofukuwonjezereka kwa oxidative metabolism.

3. Chitetezo cha Mitochondrial ndi Ma Cellular Stress

Zimawonjezerakupulumuka kwa ma cell pansi pa zovuta za metabolic kapena oxidativemikhalidwe.
Imawonjezera mawonekedwe a majini okhudzana ndikukonza ma cell ndi autophagy.

4. Zamtima ndi Neuroprotective Potential

Kafukufuku woyambirira akuwonetsa kuti MOTS-c ikhoza kutetezavascular endothelial cellndi kuchepetsa zizindikiro za kupsinjika kwa mtima.
Mphamvu za neuroprotective kudzeraanti-yotupa ndi antioxidative njiraakufufuzidwa.

Kupanga kwa API ndi Makhalidwe Abwino

At Gulu Gentolex, wathuMOTS-c APIamapangidwa pogwiritsa ntchitosolid-phase peptide synthesis (SPPS)pansi pamikhalidwe yolimba ngati ya GMP, kuwonetsetsa kuti ali apamwamba kwambiri, achiyero, komanso kukhazikika kwa kafukufuku ndi ntchito zochizira.