L-carnitine ndikuthandizira kunyamula maofesi a acid-utali wa acid

Ntchito ndi gawo

L-carnitine ilinso ndi zolimbikitsa pamwambo wamakono wamagetsi ndi nayitrogeni kagayidwe.

1. Khazikitsani mayendedwe ndi oxidation ya mafuta acids a asidi a β-oxidation wa mafuta acids amachitika mu mitochondria ya chiwindi ndi minyewa ina. Amadziwika kuti kunenepa a acid kapena mafuta a acyl-coa kumatha kudutsa mu nembanemba yamkati, motero ndikutsimikizira kuti L-carnitine imachotsa mafuta a ma membrane a acyl oyendetsa acyl kuchokera kunja. Makina atsatanetsatane a mayendedwe awa sakudziwika, koma ndi zotsimikizika kuti corrombotliotlitliotlitch-coatransfesera (carratineutl-coatransfeser-coatransfeserase) ndiye enzyme munjira iyi. Anthu ena amaganiza kuti L-carnitine amathanso kutenga nawo mbali pamagalimoto ena a acyl, kotero zimatha kuletsa thupi kuchokera poizoni wa acyl kapena kuwongolera kagayidwe ka amino-tchent.

2. Imathandizira kusasitsa kwamphamvu ndikusintha nyonga ya L-carnitine ndi mphamvu yothetsera umuna, yemwe ali ndi ntchito yowonjezera umuna wowerengeka komanso wamphamvu. Kafukufuku wamkulu wa amuna 30 akuwonetsa kuti kuchuluka kwa umuna ndi kuchuluka kwa L-carnitine mu kadyedwe kambiri, ndipo zomwe zili l-carnitine mu L-carnitine mu chakudya.

3. Kusintha kulekerera thupi la Watanabebe et al. anapeza kuti L-carnitine imatha kusintha odwala omwe ali ndi matenda olimbitsa thupi pochita masewera olimbitsa thupi, mayamwidwe a acidgen, otumphukira, owonjezera mthupi atawongolera carnitine, padzakhala kusintha kwa ma digirini; Pakamwa L-carnitine amathanso kuwonjezera kulolerana ndi minofu kwa oxygen pofika 80%, akufupikitsa nthawi yobwezeretsa pambuyo pa masewera olimbitsa thupi, ndikuchepetsa kutopa komwe kumachitika chifukwa chochita masewera olimbitsa thupi. Santulli et al. Zopezeka mu 1986 kuti L-carnitine imatha kuwonjezera kuchuluka kwa chilema choyera komanso kuchepetsa zomwe zachulukidwe ndi triglyceride mu nsomba. Germany adanenanso kuti atatenga L-carnitine kwa milungu itatu, mafuta a othamanga amatsika kwambiri, ndipo kuchuluka kwa mapuloteni kunawonjezeka, koma thupi silinakhudzidwe.