Ibutamoren Mesylate imawonjezera kulemera kwa thupi, seramu igf-1 ndi GH

Kaonekeswe

Ibramon Mesylate ndi mankhwala omwe amachita ngati mphamvu yamphamvu, yomwe imapangitsa kukula kwa mahomoni, yolimbikitsa kwambiri, ndikulongosola zochita za GH kuti mulimbikitse mahomoni a Endotous.

Kugwira nchito

Ibramon Mesylate wawonetsedwa kuti akuwonjezere kutulutsidwa ndikupanga kuchuluka kwa ma prormas a mahomoni ena kuphatikiza ma gh ndi insulin, 1), koma sikukhudza kuchuluka kwa cortisol. Mankhwala omwe angakhalepo pamavuto a mahomoniwa, monga ana kapena okalamba omwe amawonetsa kuchuluka kwa minofu, ndipo maphunziro amtundu wa anthu awonetsa chithandizo cha minofu yolimba. Zimasinthanso kagayidwe ka mafuta amthupi, motero atha kukhala ndi mapulogalamu pochizira kunenepa kwambiri.

Mu viva maphunziro

Ibutamoren Mesylate (5 mg / kg / tsiku) imapangitsa kuti ziwerengero zichulukitse kulemera kwa thupi ndikuwonjezera magawo a seramu-1 ndi ma agalu. Ibutomoren Mesylate imapangitsa kuwonjezeka kwakukulu mu CSF igf-1 kapena Gr kwa masiku 7 kapena 15 pa phunziroli. Mbewa zokhoma ndi gh masitepe a neurons awa ndi ibutomoren mesylate (50 μg, ip). Mu mbewa ya knomaut, onse a ghorrerotide amalephera kuyika Ibutotoren Mesylate kuchititsa ma neurons. Matendawa oyang'anira mkamwa a MK-0677 amagwirizanitsidwa ndi kuwonjezeka kwakukulu komwe kumachulukanso mu GH ndi igf-I Magemu omwe amasungidwa nthawi yayitali mankhwalawa. Mbiri ya GH motsatira MK-0677 Administration imakhala ndi kuchuluka kwa episodic. Mk-0677 amawonjezera kwambiri peak gh grasts pambuyo pakamwa. Mk-0677 ndi mlembi wa rof zomwe zimapangitsa kuwonjezeka kwapafupi, kwakukulu, mpaka kalekale mu gh gh pamene kutumikiridwa pakamwa kapena IV