Hexarelinndi zopangirakukula kwa secretagogue peptide (GHS)ndi wamphamvuGHSR-1a agonist, opangidwa kuti azilimbikitsakutulutsidwa kwa endogenous growth hormone (GH).. Ndi yaghrelin mimetic banjandipo imapangidwa ndi ma amino acid asanu ndi limodzi (hexapeptide), omwe amapereka kukhazikika kwa metabolic komanso kutulutsa kwamphamvu kwa GH poyerekeza ndi ma analogi akale monga GHRP-6.
Hexarelin amaphunziridwa kwambiri chifukwa cha ntchito zakeendocrinology, kuwonongeka kwa minofu, kukonza mtima, ndi mankhwala oletsa kukalamba, chifukwa cha kuthekera kwake kukweza mwachilengedwe GH ndiinsulin-ngati kukula factor 1 (IGF-1)misinkhu popanda mwachindunji kuyambitsa mahomoni akunja.
Hexarelin imamangiriza kukukula kwa hormone secretagogue receptor (GHSR-1a)pa pituitary ndi hypothalamus, kutsanzira zochita zaghrelin-njala yachilengedwe ya thupi ndi mahomoni otulutsa GH.
Zochita zazikulu zakuthupi:
Imalimbikitsa kumasulidwa kwa GH
Imawonjezera kuzunguliraIGF-1milingo
Imalimbikitsazotsatira za anabolic(kukula kwa minofu, kuchira)
Imathandiziramafuta metabolismndikusinthika kwa maselo
Mutha kuwonetsacardioprotectivendianti-apoptoticzotsatira
Mosiyana ndi ma peptides ena a GHS, Hexarelin amachitasikuwonjezera kwambiri cortisol kapena prolactin, kupereka mbiri yoyera ya endocrine.
Imalimbikitsakuonda thupichitukuko
Zimawonjezerakukonza minofu ndi kusinthika
Anaphunzira kusarcopenia, cachexia, ndi kuchira pambuyo pa opaleshoni
Maphunziro a preclinical akuwonetsabwino ntchito ya mtimapambuyo pa kuvulala kwa myocardial
Amachepetsamtima fibrosisndi kuwonjezerakumanzere kwa ventricular ejection
Zopezeka mukulephera kwa mtimandikukalamba kwa mtimazitsanzo
Kuwonjezekalipolysisndi bwinoinsulin sensitivity
Imathandiziramankhwala oletsa kukalambakudzera mu kukondoweza kwa GH/IGF-1 axis
Itha kukuthandizanikachulukidwe mafupa ndi olowa thanzi
Kuyera ≥ 99%
Kupangidwa kudzerasolid-phase peptide synthesis (SPPS)
Miyezo yofanana ndi GMP, endotoxin yochepa ndi zotsalira zosungunulira
Flexible supply:R&D kumlingo wamalonda