Glucagon

Glucagon API

Glucagon ndi mahomoni achilengedwe a peptide omwe amagwiritsidwa ntchito ngati chithandizo chadzidzidzi kwa hypoglycemia yayikulu ndipo amawerengedwa chifukwa cha gawo lake pakuwongolera kagayidwe kachakudya, kuchepa thupi, komanso kugaya chakudya.

Njira & Kafukufuku:

Glucagon imamangiriza ku glucagon receptor (GCGR) m'chiwindi, ndikuyambitsa:

Kuwonongeka kwa glycogen kuti muwonjezere shuga wamagazi

Lipolysis ndi kulimbikitsa mphamvu

M'mimba motility modulation (yogwiritsidwa ntchito mu radiology)

Ikuwunikidwanso mu kunenepa kwambiri, mtundu wa 2 shuga, komanso awiri/atatu agonist mankhwala ndi GLP-1 ndi GIP.

Mawonekedwe a API (Gentolex Gulu):

Peptide yoyera kwambiri (≥99%)

Opangidwa kudzera pa solid-phase peptide synthesis (SPPS)

GMP-ngati khalidwe

Yoyenera kubayidwa ndi zida zadzidzidzi

Glucagon API ndiyofunikira pakupulumutsidwa kwa hypoglycemia, kulingalira kwa matenda, komanso kafukufuku wa metabolic disorder.