Fmoc-L-Ls[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Ls[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Ntchito Yofufuza:
Chophatikizika ichi ndi chochokera ku lysine chosinthidwa chomwe chimagwiritsidwa ntchito popanga peptide, makamaka popanga ma conjugates olunjika kapena amitundu yambiri. Gulu la Fmoc limalola kuphatikizika kwapang'onopang'ono kudzera pa Fmoc solid-phase peptide synthesis (SPPS). Unyolo wam'mbali umasinthidwa ndi chochokera ku stearic acid (Ste), γ-glutamic acid (γ-Glu), ndi zolumikizira ziwiri za AEEA (aminoethoxyethoxyacetate), zomwe zimapereka hydrophobicity, katundu wacharge, komanso malo osinthika. Amaphunziridwa nthawi zambiri chifukwa cha gawo lake pamakina operekera mankhwala, kuphatikiza ma antibody-drug conjugates (ADCs) ndi ma peptides olowa m'maselo.

Ntchito:
Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH imagwira ntchito ngati chomangira chopangira ma peptides atalitali atalitali kapena olumikizana ndi mankhwala. Asidi ya stearic imathandizira kuyanjana kwa membrane, γ-Glu imathandizira kukhazikika komanso kukana kwa enzymatic, ndipo zolumikizira za AEEA zimapereka kusungunuka komanso kusinthasintha kwamapangidwe. Pamodzi, izi zimapangitsa kuti gululi likhale lofunika popanga ma peptides kuti apititse patsogolo bioavailability, kumasulidwa kolamuliridwa, komanso ntchito zoperekera zomwe akutsata.