Fmoc-L-Ls[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Ls[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Ntchito Yofufuza:
Pawiri izi ndi otetezedwa, functionalized lysine zotumphukira ntchito peptide kaphatikizidwe ndi mankhwala conjugate chitukuko. Imakhala ndi gulu la Fmoc la chitetezo cha N-terminal, ndi kusintha kwa unyolo wam'mbali ndi Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), ndi AEEA (aminoethoxyethoxyacetate). Zidazi zidapangidwa kuti ziphunzire za lipidation, chemistry ya spacer, komanso kutulutsidwa kwa mankhwala olamulidwa. Amafufuzidwa kwambiri potengera njira za mankhwala, zolumikizira za ADC, ndi ma peptides olumikizana ndi membrane.

Ntchito:
Fmoc-L-Ls[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH imagwira ntchito ngati chomangira chopangira ma peptides osinthidwa ndi lipid kapena njira zoperekera mankhwala. The Eic moiety bwino lipophilicity ndi nembanemba kumanga; γ-Glu imawonjezera kukhazikika kwa enzymatic ndi kuthekera kolunjika; ndipo AEEA imagwira ntchito ngati cholumikizira cha hydrophilic. Pamodzi, amathandizira kupanga ma peptide okhala ndi ma cellular owonjezera, moyo wotalikirapo, komanso malo operekera malo enieni.