Etelcalcetide Hydrochloride

Etelcalcetide Hydrochloride API
Etelcalcetide Hydrochloride ndi buku lopangidwa ndi peptide calcimimetic lomwe linapangidwira kuchiza hyperparathyroidism (SHPT) kwa odwala omwe ali ndi matenda a impso (CKD) omwe akudwala hemodialysis. SHPT ndizovuta komanso zovuta kwambiri kwa odwala CKD, omwe amadziwika ndi kuchuluka kwa mahomoni a parathyroid (PTH), kusokoneza kagayidwe ka calcium-phosphate, komanso chiopsezo chowonjezeka cha mafupa ndi matenda a mtima.

Etelcalcetide imayimira m'badwo wachiwiri wa calcimimetic, womwe umaperekedwa kudzera m'mitsempha, ndipo umapereka zabwino pamankhwala amkamwa akale monga cinacalcet powongolera kutsata komanso kuchepetsa zotsatira zoyipa za m'mimba.

Njira Yochitira
Etelcalcetide imagwira ntchito pomanga ndi kuyambitsa calcium-sensing receptor (CaSR) yomwe ili pama cell a parathyroid gland. Izi zimatsanzira physiological zotsatira za extracellular calcium, zomwe zimatsogolera ku:

Kuchepetsa kutulutsa kwa PTH

Kuchepetsa kuchuluka kwa calcium ndi phosphorous m'magazi

Kuwongolera bwino kwa mineral balance ndi mafupa a metabolism

Monga peptide yochokera ku allosteric activator ya CaSR, Etelcalcetide imawonetsa kutsimikizika kwapamwamba komanso ntchito yokhazikika pambuyo poyang'anira mtsempha pambuyo pa dialysis.

Kafukufuku wa Zachipatala ndi Zotsatira Zamankhwala
Etelcalcetide yawunikidwa mozama m'mayesero azachipatala a gawo 3, kuphatikiza maphunziro a EVOLVE, AMPLIFY, ndi EQUIP. Zotsatira zazikulu ndi izi:

Kuchepetsa kwakukulu komanso kosalekeza kwa milingo ya PTH mwa odwala CKD pa hemodialysis

Kuwongolera kogwira mtima kwa seramu calcium ndi phosphorous, zomwe zimathandizira kukonza bwino kwa fupa-mineral homeostasis

Kulekerera bwino poyerekeza ndi calcimimetics yapakamwa (kuchepa kwa nseru ndi kusanza)

Kupititsa patsogolo kutsata kwa odwala chifukwa cha kayendetsedwe ka IV katatu pa sabata panthawi ya dialysis

Zopindulitsa izi zimapangitsa Etelcalcetide kukhala njira yofunikira yochizira kwa akatswiri a nephrologists kuyang'anira SHPT mu dialysis anthu.

Quality ndi Kupanga
Etelcalcetide Hydrochloride API yathu:

Amapangidwa kudzera mu solid-phase peptide synthesis (SPPS) yoyera kwambiri

Zimagwirizana ndi zomwe zalembedwa m'makalasi amankhwala, oyenera jekeseni

Imawonetsa milingo yotsika ya zosungunulira zotsalira, zonyansa, ndi ma endotoxins

Ndi scalable pakupanga magulu akulu-gulu GMP