Mtengo wa CJC-1295

CJC-1295 API

Mtengo wa CJC-1295ndi analogue ya peptide yopangidwa ndi tetrasubstitutedkukula kwa hormone yotulutsa hormone (GHRH), yopangidwa kutikulimbikitsa ndi kusunga katulutsidwe ka endogenous growth hormone (GH). Mosiyana ndi GHRH yakubadwa, yomwe ili ndi theka la moyo waufupi, CJC-1295 imaphatikizapo aUkadaulo wa Drug Affinity Complex (DAC)., kulola kumangiriza covalently kwa albumin m'magazi nditalikitsa theka la moyo wake mpaka masiku 8. Izi zatsopano zimapangitsa CJC-1295 kukhala aanalogue ya GHRH yayitalindi kuthekera kwakukulu muanti-kukalamba, kuchepa kwa kukula, kuwongolera kagayidwe kachakudya, kuwonongeka kwa minofu, ndi mankhwala obwezeretsa.

Njira Yochitira

CJC-1295 imagwira ntchito paGHRH receptorili pa maselo a somatotropic mu anterior pituitary gland. Ntchito yake yachilengedwe imatsanzira ya GHRH yakubadwa, koma yokhala ndi theka la moyo wotalikirapo chifukwa cha kusinthidwa kwa DAC. Izi zokhazikika zimathandizirakumasulidwa kokhazikika kwa GHndi kuchuluka kwa kupangainsulin-ngati kukula factor 1 (IGF-1).

Njira zazikuluzikulu zikuphatikiza:

• Kukondoweza kwa endogenous GH secretion

• Kutalika kwa nthawi yayitali kwa IGF-1, kuthandizira zotsatira za anabolic

• Palibe deensitization yayikulukapena kuchepetsa ndikugwiritsa ntchito mosalekeza

• Kupititsa patsogolo lipolysis, kaphatikizidwe ka mapuloteni, ndi kusinthika kwa ma cell

Poyambitsa njira za thupi la GH ndi IGF-1, CJC-1295 imapewa zovuta zambiri zomwe zimagwirizanitsidwa ndi mankhwala amtundu wa GH, monga receptor deensitization ndi nkhawa za chitetezo.

Kafukufuku Wochiritsira ndi Kuthekera Kwachipatala

1. Kuchuluka kwa Hormone Deficiency (GHD)

M'mayesero oyambilira achipatala, CJC-1295 yawonetsa:

• Kuwonjezeka pang'onoGHndiIGF-1ma level mpaka6-10 masikupambuyo jekeseni kamodzi

• Zachepetsedwapafupipafupi jakisonipoyerekeza ndi GHRH analogues tsiku lililonse kapena GH jakisoni

• Kupititsa patsogolo kutsata kwa odwala komanso kukhazikika kwa mahomoni

2. Maonekedwe a Thupi ndi Kusunga Minofu

Kafukufuku wa nyama ndi anthu awonetsa kuti CJC-1295:

• Imalimbikitsakupindula kwa minofu yowondandiamachepetsa mafuta a thupi, makamaka mafuta a visceral

• Zimawonjezerakusungirako nayitrogeni ndi kaphatikizidwe ka mapulotenimu minofu ya chigoba

• Itha kukuthandizani kuchirasarcopeniandi mikhalidwe yowononga minofu

3. Anti-Kukalamba ndi Ubwino Mapulogalamu

Pamene milingo ya GH ndi IGF-1 imatsika mwachilengedwe ndi zaka, CJC-1295 imawerengedwa mokulira ngatianti-aging interventionku:

• Sinthanikugona bwinondicircadian rhythm regulation

• Limbikitsanikhungu elasticity, fupa kachulukidwe,ndichitetezo cha mthupi

• Thandizomphamvu metabolismndikukana kutopa

4. Metabolic Regulation

CJC-1295 ikuwonetsa kulonjeza poyankhakukana insulinimetabolic syndrome ndi: +

• Kuwongolerakugwiritsa ntchito glucose

• Kuwonjezeralipid oxidationndiadipose minofu metabolism

• Kuthandizirakasamalidwe kulemeramwa anthu onenepa kwambiri kapena omwe ali ndi matenda ashuga

Kupanga API ndi Kuwongolera Ubwino

At Gulu Gentolex, wathuCJC-1295 APIamapangidwa pogwiritsa ntchitosolid-phase peptide synthesis (SPPS)ndikuyeretsedwa pogwiritsa ntchito HPLC kuti ikwaniritse chiyero chapamwamba komanso kusasinthika kwa batch-to-batch.

Zofunika Kwambiri:

• Kuyera ≥ 99%(HPLC yatsimikiziridwa)

• Low zotsalira zosungunulira ndi heavy metals

• Endotoxin-free, non-immunogenic synthesis njira

• Ikupezeka mukuchuluka kwachizolowezi: milligram mpaka kilogalamu sikelo

Mapulogalamu ndi Zamtsogolo Zamtsogolo

CJC-1295 imatengedwa kuti ndi imodzi mwazofananira za GHRH zomwe zakhala zikugwira kwa nthawi yayitali, zomwe zitha kugwiritsidwa ntchito mu:

• Chithandizo chochepa cha GH chachikulu

• Kuwongolera kapangidwe ka thupi mu kunenepa kwambiri komanso ukalamba

• Kukonzanso kuchokera ku kutaya minofu kapena kuvulala

• Kupititsa patsogolo kagwiridwe ndi kuchira muzochitika zachipatala kapena zamasewera

• Thandizo lothandizira mu kutopa kosatha, fibromyalgia, ndi kusalinganika kwa neuroendocrine

Mayesero opitilira azachipatala akuwunika kugwiritsa ntchito kwake ngati njira inarecombinant GH, makamaka pa anthu omwe akufunafunamotetezeka, kusinthasintha kwamphamvu kwa mahomoni.