Tirzepatide

Tirzepatide API
Tirzepatide ndi peptide yopangidwa yomwe imagwira ntchito ngati ma agonist awiri a glucose-wodalira insulinotropic polypeptide (GIP) ndi glucagon-like peptide-1 (GLP-1) receptors. Ikuyimira kalasi yatsopano yamankhwala opangidwa ndi incretin omwe amadziwika kuti "twincretins", omwe amapereka kuwongolera kagayidwe kachakudya kwa odwala omwe ali ndi matenda amtundu wa 2 komanso kunenepa kwambiri.

API yathu ya Tirzepatide imapangidwa ndi njira zapamwamba zophatikizira mankhwala, kuwonetsetsa chiyero chambiri, milingo yocheperako, komanso kusasinthika kwa batch-to-batch. Mosiyana ndi ma peptide opangidwa ndi rDNA, API yathu yopangira imakhala yopanda mapuloteni a cell ndi DNA, kuwongolera kwambiri chitetezo cham'madzi komanso kutsata malamulo. Njira zopangira zidakonzedweratu kuti zitheke kuti zikwaniritse zomwe zikukula padziko lonse lapansi.

Njira Yochitira
Tirzepatide imagwira ntchito nthawi imodzi kulimbikitsa onse GIP ndi GLP-1 zolandilira, kupereka zotsatira zowonjezera ndi synergistic:

GIP receptor activation: imathandizira katulutsidwe ka insulini ndipo imatha kukulitsa chidwi cha insulin.

GLP-1 receptor activation: imapondereza kutulutsidwa kwa glucagon, kuchedwetsa kutulutsa m'mimba, komanso kumachepetsa chilakolako.

Zochita zophatikizana zimapangitsa kuti:

Kuwongolera bwino kwa glycemic control

Kuchepetsa kulemera kwa thupi

Kukhuta kumawonjezera komanso kuchepetsa kudya

Kafukufuku wa Zachipatala & Zotsatira
Tirzepatide yawonetsa mphamvu zomwe sizinachitikepo m'mayesero akuluakulu angapo azachipatala (SURPASS & SURMOUNT mndandanda):

Kuchepetsa kwapamwamba kwa HbA1c poyerekeza ndi GLP-1 RAs (mwachitsanzo, Semaglutide)

Kuchepetsa thupi mpaka 22.5% mwa odwala onenepa kwambiri - poyerekeza ndi opaleshoni ya bariatric nthawi zina

Kuyamba kofulumira komanso kuwongolera kwa glycemic pakugwiritsa ntchito nthawi yayitali

Zolemba bwino za cardiometabolic: kuphatikiza kuthamanga kwa magazi, lipids, ndi kutupa

Tirzepatide sikuti imangosintha mawonekedwe a chithandizo cha matenda amtundu wa 2 komanso akuwoneka ngati njira yayikulu yochizira matenda ochepetsa thupi komanso metabolic syndrome.

Quality & Compliance
API Yathu ya Tirzepatide:

Imakwaniritsa miyezo yapadziko lonse lapansi (FDA, ICH, EU)

Kuyesedwa kudzera pa HPLC pamilingo yotsika ya zonyansa zodziwika komanso zosadziwika

Amapangidwa pansi pamikhalidwe ya GMP yokhala ndi zolemba zonse

Thandizani kupanga kwakukulu kwa R&D