Tianeptine ya 5-HT System, sedation, anti-acetylcholine ndi Cardiotaxioline ndi Cardiotaxiolicity wa kukhumudwa

Pharmacological zotsatira

1. Makina antidepressant a malonda awa ndi osiyana ndi a TCA yachikhalidwe. Zimatha kuwonjezera patali ndi 5-ht mu synaptic cleft, koma imafota kwambiri pakubwezeretsanso 5-ht ndi na. Atha kukhala ndi zotsatira zowonjezera kufalikira kwa 5-HT neuronal. Ilibe ubale chifukwa cha olandila, H1, í1 ndi í1 ndi í1-na receptors.
2. Chithandizo cha antidepreschent cha mankhwalawa ndi ofanana ndi tca, ndipo kutetezedwa ndi kulolera kwake kuli bwino kuposa tca (tricyclic antidepressants). Chotheka pazinthu izi ndizofanana ndi za SSri Fluoxetine.
3. Kuyesedwa kwa mankhwala a nyama kwawonetsa kuti zitha: Kuchulukitsa zochitika za ma piramidi mu hippocampus ndikuwonjezera kuchira kwa ntchito yake pambuyo pa ntchito yake. Onjezani rebsorption ya 5-hydroxtryptine ndi ma neuron mu cellul cortex ndi hippocampus.

Kafukufuku Wowonjezera

- pachimake, kuperewera kwadzidzidzi ndi kwa nthawi yayitali: Palibe kusintha kwa sayansi, kugwiritsidwa ntchito kwa chiwindi, matendawa.
- Kuletsa kwa teracticity ndi mayeso a teratogenicity: Tianeptine alibe mphamvu kukhoza kwa makolo omwe ali ndi zaka fetus ndi ana.
- Kuyesa kwa Mutagenic: Tianeptine alibe Mutagenic zotsatira.

Zotsatira zoyipa

- Kupweteka kwa epigastric, kupweteka pamimba, pakamwa pouma, kupweteka kwa mankhwala a anorexia, kusanza, kudzimbidwa, kufufukula;
- kusowa tulo, kugona, kugona, zonyansa, kufooka;
- tachycardia, zowonjezera, zowawa;
- Chizungu, kupweteka mutu, kukomoka, kugwedezeka, kupukusa nkhope;
- kupuma mofupikira, kumverera kwa chigombe pakhosi;
- MyIALGIA, kupweteka kwa msana, etc.