REVERSE T3 ya kaphatikizidwe ka mapuloteni, thermoregulation, kupanga mphamvu ndi kuwongolera
Tsatanetsatane wa Zamalonda
| Dzina | KUSINTHA T3 |
| Nambala ya CAS | 5817-39-0 |
| Molecular formula | C15H12I3NO4 |
| Kulemera kwa maselo | 650.97 |
| Malo osungunuka | 234-238 ° C |
| Malo otentha | 534.6±50.0°C |
| Chiyero | 98% |
| Kusungirako | Sungani pamalo amdima, osindikizidwa pouma, Sungani mufiriji, pansi pa -20°C |
| Fomu | Ufa |
| Mtundu | Pale Beige kupita ku Brown |
| Kulongedza | Chikwama cha PE + Chikwama cha Aluminium |
Mawu ofanana ndi mawu
ReverseT3(3,3',5'-Triiodo-L-Thyronine);L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-;(2S) -2-aMino-3-[4-(4-hydroxy-3,5-diiodophe) noxy) -3-iodophenyl]propanoicacid;REVERSET3;T3;LIOTHYRONIN;L-3,3',5'-TRIIODOTHYRONINE;3,3′,5′-Triiodo-L-thyronine(ReverseT3) njira
Pharmacological Effect
Kufotokozera
Chithokomiro ndicho chithokomiro chachikulu kwambiri cha endocrine m'thupi la munthu, ndipo zinthu zazikulu zomwe zimagwira ntchito ndi tetraiodothyronine (T4) ndi triiodothyronine (T3), zomwe ndizofunikira kwambiri pakupanga mapuloteni, kuwongolera kutentha kwa thupi, kupanga mphamvu ndi udindo wowongolera. Ambiri a T3 mu seramu amatembenuzidwa kuchokera ku zotumphukira minofu deiodination, ndipo gawo laling'ono la T3 mwachindunji kutulutsidwa ndi chithokomiro ndi kumasulidwa m'magazi. Ambiri a T3 mu seramu amamanga mapuloteni, pafupifupi 90% omwe amamangiriridwa ku thyroxine-binding globulin (TBG), ena onse amamangidwa ku albumin, ndipo ochepa kwambiri amamangidwa ku thyroxine-binding prealbumin (TBPA). Zomwe zili mu T3 mu seramu ndi 1/80-1/50 ya T4, koma zochita zachilengedwe za T3 ndi 5-10 kuchulukitsa kwa T4. T3 imagwira ntchito yofunikira pakuweruza momwe thupi la munthu lilili, kotero ndikofunikira kwambiri kuzindikira zomwe zili mu T3 mu seramu.
Kufunika Kwachipatala
Kutsimikiza kwa triiodothyronine ndi chimodzi mwa zizindikiro zodziwika bwino za hyperthyroidism. Pamene hyperthyroidism ikuwonjezeka, imakhalanso kalambulabwalo wa kuyambiranso kwa hyperthyroidism. Kuonjezera apo, zidzawonjezeka pa nthawi ya mimba komanso pachimake chiwindi. Hypothyroidism, losavuta goiter, pachimake ndi aakulu nephritis, matenda a chiwindi, matenda enaake chiwindi utachepa. Kuphatikizika kwa Serum T3 kumawonetsa ntchito ya chithokomiro pamagulu ozungulira m'malo mwachinsinsi cha chithokomiro. Kutsimikiza kwa T3 kungagwiritsidwe ntchito pozindikira T3-hyperthyroidism, kuzindikira koyambirira kwa hyperthyroidism ndi matenda a pseudothyrotoxicosis. Mulingo wathunthu wa seramu T3 nthawi zambiri umagwirizana ndi kusintha kwa T4. Ndi chizindikiro chodziwika bwino cha matenda a chithokomiro, makamaka pozindikira msanga. Ndi chizindikiro chodziwikiratu cha T3 hyperthyroidism, koma ilibe phindu pakuzindikiritsa ntchito ya chithokomiro. Kwa odwala omwe amathandizidwa ndi mankhwala a chithokomiro, ayenera kuphatikizidwa ndi thyroxine (TT4) yonse ndipo, ngati n'koyenera, thyrotropin (TSH) nthawi yomweyo kuti athandize kuweruza momwe chithokomiro chimagwirira ntchito.
