Zogulitsa
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Givosiran
Givosiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) yophunzirira pochiza pachimake kwa chiwindi porphyria (AHP). Imalimbana makamaka ndiALAS1jini (aminolevulinic acid synthase 1), yomwe imakhudzidwa ndi njira ya heme biosynthesis. Ofufuza amagwiritsa ntchito Givosiran kuti afufuze njira zochiritsira za RNA interference (RNAi), kuletsa jini yolimbana ndi chiwindi, komanso kusintha kwa kagayidwe kachakudya kamene kamayambitsa porphyria ndi matenda okhudzana ndi majini.
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Pegcetacoplan
Pegcetacoplan ndi pegylated cyclic peptide yomwe imagwira ntchito ngati C3 complement inhibitor, yomwe imapangidwira kuchiza matenda ophatikizana monga paroxysmal nocturnal hemoglobinuria (PNH) ndi geographic atrophy (GA) muzaka zokhudzana ndi macular degeneration.
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Plozasiran
Plozasiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) komwe kamapangidwira kuchiza hypertriglyceridemia ndi matenda okhudzana ndi mtima ndi kagayidwe kachakudya. Imalimbana ndiAPOC3jini, yomwe imayika apolipoprotein C-III, wowongolera kwambiri wa triglyceride metabolism. Pofufuza, Plozasiran amagwiritsidwa ntchito pophunzira njira zochepetsera lipids za RNAi, gene-sencing specificity, ndi mankhwala okhalitsa kwa nthawi yaitali monga matenda a chylomicronemia syndrome (FCS) ndi dyslipidemia yosakanikirana.
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Zilebesiran
Zilebesiran API ndi kafukufuku waung'ono wosokoneza RNA (siRNA) wopangidwa kuti azichiza matenda oopsa. Imalimbana ndiAGTjini, yomwe imayika angiotensinogen - chigawo chachikulu cha renin-angiotensin-aldosterone system (RAAS). Pofufuza, Zilebesiran amagwiritsidwa ntchito pophunzira njira zochepetsera ma jini pakuwongolera kuthamanga kwa magazi kwa nthawi yayitali, matekinoloje operekera RNAi, komanso gawo lalikulu la njira ya RAAS pamtima ndi aimpso.
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Palopegteriparatide
Palopegteriparatide ndi parathyroid hormone receptor agonist (PTH1R agonist) yomwe imagwira ntchito kwa nthawi yayitali, yopangidwira kuchiza matenda a hypoparathyroidism. Ndi analogi ya pegylated ya PTH (1-34) yopangidwa kuti ipereke malamulo okhazikika a calcium ndi dosing kamodzi pa sabata.
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GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) ndi hexapeptide yopangidwa yomwe imakhala ngati secretagogue ya kukula kwa hormone, yomwe imalimbikitsa kutulutsidwa kwachilengedwe kwa hormone ya kukula (GH) poyambitsa GHSR-1a receptor.
Mawonekedwe a API:
Chiyero ≥99%
Opangidwa kudzera pa solid-phase peptide synthesis (SPPS)
Amaperekedwa kwa R&D ndikugwiritsa ntchito malonda
GHRP-6 ndi peptide yosunthika yofufuza yothandizira kagayidwe kachakudya, kusinthika kwa minofu, komanso kusintha kwa mahomoni.
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GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) ndi hexapeptide yopanga komanso kukula kwamphamvu kwa secretagogue, yopangidwa kuti ipangitse kutulutsa kwachilengedwe kwa kukula kwa hormone (GH) poyambitsa cholandilira cha GHSR-1a mu hypothalamus ndi pituitary.
Mawonekedwe a API:
Chiyero ≥99%
Ikupezeka pa R&D ndikupereka zamalonda, zolembedwa zonse za QC
GHRP-2 ndi peptide yofunikira yofufuza m'magawo a endocrinology, mankhwala obwezeretsanso, komanso njira zochiritsira zokhudzana ndi zaka.
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Hexarelin
Hexarelin ndi mahomoni opangira secretagogue peptide (GHS) komanso GHSR-1a agonist yamphamvu, yopangidwa kuti ipangitse kutulutsidwa kwa endogenous kukula kwa hormone (GH). Ndi ya banja la ghrelin mimetic ndipo ili ndi ma amino acid asanu ndi limodzi (hexapeptide), yomwe imapereka kukhazikika kwa metabolic komanso kutulutsa kwamphamvu kwa GH poyerekeza ndi ma analogi akale monga GHRP-6.
Mawonekedwe a API:
Kuyera ≥ 99%
Opangidwa kudzera pa solid-phase peptide synthesis (SPPS)
Miyezo ngati GMP, endotoxin yochepa ndi zotsalira za zosungunulira
Flexible supply: R&D mpaka malonda
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Melanotan II
Mawonekedwe a API:
Kuyera kwakukulu ≥ 99%
Kupangidwa kudzera pa solid-phase peptide synthesis (SPPS)
Endotoxin yotsika, zosungunulira zotsalira zochepa
Imapezeka mu R&D mpaka masikelo amalonda -
Melanotan 1
Melanotan 1 API imapangidwa pogwiritsa ntchito ukadaulo wa solid phase peptide synthesis (SPPS) pansi pamikhalidwe yolimba ngati GMP.
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Kuyera kwakukulu ≥99%
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Solid-phase peptide synthesis (SPPS)
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Miyezo yopanga ngati GMP
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Zolemba zonse: COA, MSDS, deta yokhazikika
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Kupezeka kochulukira: R&D mpaka magawo azamalonda
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MOTS-C
MOTS-C API imapangidwa pansi pamikhalidwe yolimba ngati ya GMP pogwiritsa ntchito ukadaulo wa solid phase peptide synthesis (SPPS) kuti iwonetsetse kuti imakhala yapamwamba kwambiri, yoyera kwambiri komanso yokhazikika pakufufuza komanso kugwiritsa ntchito mankhwala.
Zogulitsa:Kuyera ≥ 99% (kutsimikiziridwa ndi HPLC ndi LC-MS),
Endotoxin yotsika komanso zosungunulira zotsalira,
Zopangidwa molingana ndi ma protocol a ICH Q7 ndi GMP,
Itha kukwaniritsa kupanga kwakukulu, kuchokera pamagulu a R&D a milligram-level mpaka gram-level ndi malonda a kilogalamu. -
Ipamorelin
Ipamorelin API imakonzedwa ndi njira yapamwamba kwambiri **solid phase peptide synthesis process (SPPS)** ndipo imayesedwa kotheratu ndi kuyezetsa koyenera, koyenera kugwiritsa ntchito mapaipi oyambirira mu kafukufuku wa sayansi ndi chitukuko ndi makampani opanga mankhwala.
Zogulitsa zikuphatikiza:
Purity ≥99% (HPLC test)
Palibe endotoxin, zosungunulira zotsalira zochepa, kuipitsidwa kwa ayoni achitsulo otsika
Perekani zolemba zonse zamtundu wabwino: COA, lipoti la kukhazikika, kusanthula kwazinthu zonyansa, ndi zina.
Kupezeka kwa mulingo wa gramu ~ kilogalamu-level