Zogulitsa
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU ndi molekyulu yopangira lipidated yolumikizira yomwe idapangidwira kuti iperekedwe ndi mankhwala omwe amalimbana ndi antibody-drug conjugates (ADCs). Imakhala ndi mchira wa stearoyl (Ste) hydrophobic, γ-glutamyl yolunjika, AEEA spacers for flexibility, ndi gulu la OSu (NHS ester) lolumikizana bwino.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH ndi chomangira chotetezedwa cha tripeptide chokhala ndi α-methylated leucine, chomwe chimagwiritsidwa ntchito popanga mankhwala a peptide kuti apititse patsogolo kukhazikika kwa kagayidwe kachakudya komanso kusankha kolandirira.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) ndi chotsukira chopangira zwitterionic chomwe chimagwiritsidwa ntchito kwambiri pofufuza za protein ya membrane ndi biology yamapangidwe, makamaka mu NMR spectroscopy ndi crystallography.
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N-Acetylneuraminic Acid (Neu5Ac Sialic Acid)
N-Acetylneuraminic Acid (Neu5Ac), yomwe imadziwika kuti sialic acid, ndi monosaccharide yochitika mwachilengedwe yomwe imakhudzidwa ndi magwiridwe antchito ofunikira a ma cell ndi chitetezo chamthupi. Zimagwira ntchito yofunika kwambiri pakuzindikiritsa ma cell, kuteteza tizilombo toyambitsa matenda, komanso kukula kwa ubongo.
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Ergothioneine
Ergothioneine ndi antioxidant yochokera ku amino acid yopangidwa mwachilengedwe, yophunziridwa chifukwa champhamvu ya cytoprotective ndi anti-kukalamba. Amapangidwa ndi bowa ndi mabakiteriya ndipo amaunjikana mu minofu yomwe imakhudzidwa ndi kupsinjika kwa okosijeni.
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NMN
Kafukufuku woyambirira komanso woyambirira wa anthu akuwonetsa kuti NMN ikhoza kulimbikitsa moyo wautali, kupirira kwakuthupi, komanso kuzindikira.
Mawonekedwe a API:
Kuyera kwakukulu ≥99%
Mankhwala-kalasi, oyenera pakamwa kapena jekeseni formulations
Amapangidwa molingana ndi miyezo ya GMP
NMN API ndiyabwino kuti igwiritsidwe ntchito pazowonjezera zoletsa kukalamba, machiritso a metabolism, ndi kafukufuku wa moyo wautali.
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Glucagon
Glucagon ndi mahomoni achilengedwe a peptide omwe amagwiritsidwa ntchito ngati chithandizo chadzidzidzi kwa hypoglycemia yayikulu ndipo amawerengedwa chifukwa cha gawo lake pakuwongolera kagayidwe kachakudya, kuchepa thupi, komanso kugaya chakudya.
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Motixafortide
Motixafortide ndi peptide yotsutsana ndi CXCR4 yopangidwa kuti ilimbikitse maselo amtundu wa hematopoietic (HSCs) kuti alowetsedwe ndi autologous ndipo akuphunziridwanso mu oncology ndi immunotherapy.
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Glepaglutide
Glepaglutide ndi analogue ya GLP-2 yanthawi yayitali yopangidwira kuchiza matenda am'mimba (SBS). Imawonjezera kuyamwa kwamatumbo ndi kukula, kuthandiza odwala kuchepetsa kudalira zakudya za makolo.
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Elamipretide
Elamipretide ndi tetrapeptide yomwe imayang'aniridwa ndi mitochondria yopangidwa kuti ichiritse matenda omwe amayamba chifukwa cha kusagwira bwino ntchito kwa mitochondrial, kuphatikiza mitochondrial myopathy, matenda a Barth, ndi kulephera kwa mtima.
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Donilorsen
Donilorsen API ndi antisense oligonucleotide (ASO) yomwe ikufufuzidwa pochiza angioedema ya cholowa (HAE) ndi zina zotupa. Amaphunziridwa mu nkhani ya RNA-zochizira, cholinga kuchepetsa kufotokozaplasma prekallikrein(KLKB1 mRNA). Ofufuza amagwiritsa ntchito Donidalorsen kuti afufuze njira zochepetsera ma jini, ma pharmacokinetics omwe amadalira mlingo, komanso kuwongolera kwanthawi yayitali kwa kutupa kwa bradykinin.
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Fitusiran
Fitusiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) komwe kumafufuzidwa makamaka pankhani ya hemophilia ndi matenda a coagulation. Imalimbana ndiantithrombin (AT kapena SEPINC1)jini m'chiwindi kuti achepetse kupanga kwa antithrombin. Ofufuza amagwiritsa ntchito Fitusiran kuti afufuze njira za RNA interference (RNAi), kuletsa jini yeniyeni ya chiwindi, ndi njira zatsopano zochiritsira zochepetsera coagulation mu hemophilia A ndi B odwala, kapena opanda zoletsa.