Pregabalin yochizira zopereka za nealheral neuralgia ndi zomwe zimachitika mwadzidzidzi

Pharmacological zotsatira
Pregabalnin ali ndi achire bwino pa khunyu. Kafukufuku wamitundu yosiyanasiyana ya nyama yam'madzi yawonetsa kuti pregabalin imatha kupewa kukomoka kwa khunyu, ndipo mlingo wake wogwira ndi nthawi 3-10 kuposa gabapentin. Kafukufuku wapeza kuti Pregabalin amatha kuchepetsa mawonekedwe ndi chingwe chamoto chowoneka bwino cha mitsempha ya neuropathic chinyama cha neuropathic ndi vuto lolumikizidwa msana. machitidwe a. Kafukufuku wa nyama wapeza kuti Pregabalkin akhoza kukhala ndi zabwino kuphatikiza ndi opioids. Pregabalnin imapereka njira yatsopano yothandizira matenda a neuropathic.

Chinthu
Pregabalnin imatha kuchepetsa kutulutsa kwa calcium-nerotransts pogwiritsa ntchito cal cal calkium njira yanyimbo. Ngakhale PregabalIn ndi yopanda kapangidwe ka neurotransmitter γ ubongo wa makoswe, ndipo alibe mphamvu pa Gaba uptala up kapena kuwonongeka. Komabe, kafukufukuyu adazindikira kuti nthawi yayitali yopenyerera kupita ku pregabalin yowonjezera kuchuluka kwa ma Gaba ndi kuchuluka kwa magalimoto ogwiritsira ntchito Gaba. Pregabalnin saletsa njira ya sodium, alibe ntchito pa opioid receptors, sasintha zochitika pa Dopamine ndi Serotonin, kapena Norepinefonirine. Ingwala.

Zogwirizana
1. Sizimapukutidwa ndi dongosolo la cytochrome P450, chifukwa chake simakhala ndi mankhwala ena. Sizimakhudzanso mankhwala a antiepileptic mankhwala (monga sodium vamproate, phenytobarrigine, prourazerbine, okopera pakamwa, okodzetsa, ndi insulin.
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3. Ili ndi zowonjezera ndi Lorazepam ndi Mowa.