Plozasiran

Plozasiran (API)

Ntchito Yofufuza:
Plozasiran API ndi kaphatikizidwe kakang'ono kosokoneza RNA (siRNA) komwe kamapangidwira kuchiza hypertriglyceridemia ndi matenda okhudzana ndi mtima ndi kagayidwe kachakudya. Imalimbana ndiAPOC3jini, yomwe imayika apolipoprotein C-III, wowongolera kwambiri wa triglyceride metabolism. Pofufuza, Plozasiran amagwiritsidwa ntchito pophunzira njira zochepetsera lipids za RNAi, gene-sencing specificity, ndi mankhwala okhalitsa kwa nthawi yaitali monga matenda a chylomicronemia syndrome (FCS) ndi dyslipidemia yosakanikirana.

Ntchito:
Plozasiran amagwira ntchito poletsaAPOC3mRNA m'chiwindi, zomwe zimapangitsa kuchepa kwa apolipoprotein C-III. Izi zimathandizira kuwonjezereka kwa lipolysis ndi kuchotsedwa kwa triglyceride-rich lipoproteins m'magazi. Monga API, Plozasiran imathandizira kuti pakhale chithandizo chamankhwala chokhalitsa chomwe cholinga chake ndi kuchepetsa kwambiri ma triglyceride ndi kuchepetsa chiopsezo cha kapamba ndi zochitika zamtima kwa odwala omwe ali ndi vuto lalikulu kapena lachibadwa la lipid.