PT-141 ndi chiyani?

Chizindikiro (kugwiritsa ntchito kovomerezeka): Mu 2019, a FDA adavomereza kuti azitha kuchiza matenda omwe apezeka, odziwika bwino a hypoactive (HSDD) mwa amayi omwe ali ndi vuto lotha msinkhu pamene vutoli limayambitsa kuvutika maganizo ndipo sichifukwa cha zovuta zina zachipatala / zamisala kapena zotsatira za mankhwala.

Njira Yochitira
PT-141 ndi melanocortin receptor agonist (makamaka MC4 receptor) yomwe imasintha chilakolako chogonana kudzera munjira zapakati zamanjenje.

Mosiyana ndi PDE5 inhibitors (mwachitsanzo, sildenafil), yomwe imakhudza kwambiri mitsempha ya magazi, PT-141 imagwira ntchito pakati kuti ikhudze chilakolako chogonana ndi kudzutsidwa.

Pharmacology & Dosing
Ulamuliro: jakisoni wa subcutaneous, ngati pakufunika (pofuna).
Mlingo wovomerezeka: 1.75 mg sc

Pharmacokinetics:
Tmax ≈ ~ 60 mphindi
t½ ≈ maola 2-3
Zotsatira zimatha kukhala maola angapo, mu malipoti ena mpaka ~ maola 16.
Kuchita Kwachipatala (Mayesero a Gawo III - RECONNECT, masabata a 24, RCTs)

Zomaliza zoyambira:
Female Sexual Function Index-Desire domain (FSFI-D)
Kuvutika Kugonana Kwa Akazi (FSDS-DAO)
Zotsatira zazikulu (maphunziro ophatikizidwa 301 + 302):
Kusintha kwa FSFI-D: +0.35 vs placebo (P<0.001)
Kuchepetsa kuchuluka kwa FSDS-DAO: −0.33 vs placebo (P<0.001)
Mapeto ena: Zotsatira zothandizira (ziwerengero za ntchito zogonana, kukhutitsidwa ndi odwala) zinkayenda bwino, koma zochitika zogonana zokhutiritsa (SSEs) sizinasonyeze kusiyana kwakukulu kosasinthasintha.

Zochitika Zoyipa (zomwe zimanenedwa kawirikawiri m'mayesero)
Wamba (≥10%):
Nausea (~ 30-40%; mpaka ~ 40% yanenedwa m'mayesero)
Kupukuta (≥10%)
Mutu (≥10%)

Zotsatira zamtima:
Kuwonjezeka kwapang'onopang'ono kwa kuthamanga kwa magazi ndi kusintha kwa kugunda kwa mtima kunawonedwa, kawirikawiri kuthetsa mkati mwa maola angapo.
Contraindicated kapena ntchito mosamala odwala matenda oopsa kapena matenda amtima.
Chiwindi: Malipoti osowa a kukwera kwa enzyme ya chiwindi; Malipoti osowa kwambiri akuwonetsa kuvulala kwakukulu kwa chiwindi, koma osati kofala.

Chitetezo Chanthawi Yaitali (Phunziro Lowonjezera)
Kafukufuku wowonjezera wamasabata 52 adapeza kuwongolera kwachikhumbo popanda zizindikiro zazikulu zachitetezo.
Mbiri yachitetezo chanthawi yayitali imawonedwa ngati yololera bwino, pomwe zovuta zazikulu zolekerera zikadali zobwera kwakanthawi kochepa monga nseru.

Zolemba Zofunika Kwambiri
Chiwerengero chovomerezeka ndi chochepa: Kwa amayi omwe ali ndi premenopausal omwe ali ndi HSDD yodziwika bwino.
Osavomerezeka kwambiri kwa amuna (ED kapena chikhumbo chochepa mwa amuna chimakhalabe chofufuza).
Kuwunika chitetezo ndikofunikira: kuthamanga kwa magazi, matenda amtima, komanso mbiri ya chiwindi ziyenera kuunika musanapereke mankhwala.

Chidule Chachangu cha Data
Chivomerezo cha FDA: 2019 (Vyleesi).
Mlingo: 1.75 mg subcutaneous jakisoni, pakufunika.
PK: Tmax ~ 60 min; t½ maola 2-3; zotsatira mpaka ~ 16 h.
Kuchita bwino (Gawo lachitatu, lophatikizidwa):
FSFI-D: +0.35 (P<.001)
FSDS-DAO: −0.33 (P<.001)

Zochitika zoyipa:
Nausea: mpaka ~ 40%
Kuwotcha: ≥10%
Mutu: ≥10%
Kuwonjezeka kwapang'onopang'ono kwa BP kumawonedwa.

Gulu Lofananiza & Grafu (Chidule)