Kodi NAD + ndi Chiyani Ndipo Chifukwa Chiyani Ndi Yofunika Kwambiri Paumoyo ndi Moyo Wautali?

NAD⁺ (Nicotinamide Adenine Dinucleotide) ndi coenzyme yofunikira yomwe imapezeka pafupifupi m'maselo onse amoyo, omwe nthawi zambiri amatchedwa "mamolekyu apakati amphamvu zama cell." Imagwira ntchito zingapo m'thupi la munthu, imagwira ntchito ngati chonyamulira mphamvu, yoteteza kukhazikika kwa ma genetic, komanso kuteteza magwiridwe antchito a ma cell, zomwe zimapangitsa kukhala kofunikira kuti mukhale ndi thanzi komanso kuchedwetsa ukalamba.

Mu metabolism yamphamvu, NAD⁺ imathandizira kusintha kwa chakudya kukhala mphamvu yogwiritsira ntchito. Pamene chakudya, mafuta, ndi mapuloteni zimasweka mkati mwa maselo, NAD⁺ imakhala ngati chonyamulira ma electron, kutumiza mphamvu ku mitochondria kuyendetsa kupanga ATP. ATP imagwira ntchito ngati "mafuta" amachitidwe am'manja, kuwongolera mbali zonse za moyo. Popanda NAD⁺ yokwanira, kupanga mphamvu zama cell kumachepa, zomwe zimapangitsa kuchepa kwamphamvu komanso magwiridwe antchito onse.

Kupitilira mphamvu ya metabolism, NAD⁺ imathandizira kwambiri kukonza kwa DNA komanso kukhazikika kwa ma genomic. Maselo nthawi zonse amakumana ndi kuwonongeka kwa DNA kuchokera kuzinthu zachilengedwe komanso kagayidwe kachakudya, ndipo NAD⁺ imayambitsa ma enzymes okonza kuti akonze zolakwika izi. Imayambitsanso ma sirtuins, banja la mapuloteni okhudzana ndi moyo wautali, ntchito ya mitochondrial, ndi metabolic balance. Chifukwa chake, NAD⁺ sikuti ndiyofunikira pakusunga thanzi komanso imayang'ana kwambiri pakufufuza kolimbana ndi ukalamba.

NAD⁺ ndiyofunikiranso pakuyankha kupsinjika kwa ma cell komanso kuteteza dongosolo lamanjenje. Panthawi ya kupsinjika kwa okosijeni kapena kutupa, NAD⁺ imathandizira kuwongolera ma signature a cell ndi ion balance kuti isunge homeostasis. Mu dongosolo lamanjenje, imathandizira thanzi la mitochondrial, imachepetsa kuwonongeka kwa okosijeni kwa ma neurons, ndipo imathandizira kuchedwetsa kuyambika ndikukula kwa matenda a neurodegenerative.

Komabe, milingo ya NAD⁺ mwachilengedwe imatsika ndi zaka. Kutsika kumeneku kumagwirizana ndi kuchepetsa kupanga mphamvu, kusokonezeka kwa DNA kukonza, kuwonjezeka kwa kutupa, ndi kuchepa kwa mitsempha ya mitsempha, zomwe zonsezi ndi zizindikiro za ukalamba ndi matenda aakulu. Kusunga kapena kukulitsa milingo ya NAD⁺ kotero kwakhala chinthu chofunikira kwambiri pakuwongolera zaumoyo zamakono komanso kafukufuku wamoyo wautali. Asayansi akufufuza zowonjezera ndi NAD⁺ precursors monga NMN kapena NR, komanso njira zothandizira moyo, kuti apititse patsogolo milingo ya NAD⁺, kulimbitsa mphamvu, ndi kulimbikitsa thanzi labwino.