Mounjaro (Tirzepatide) ndi mankhwala ochepetsa thupi komanso kukonza zinthu zomwe zimakhala ndi tirzepatide. Tirzepatide ndi wapawiri wapawiri GIP ndi GLP-1 receptor agonist. Ma receptor onsewa amapezeka m'maselo a pancreatic alpha ndi beta endocrine, mtima, mitsempha yamagazi, maselo a chitetezo chamthupi (leukocytes), matumbo ndi impso. GIP receptors amapezekanso mu adipocytes.
Kuphatikiza apo, GIP ndi GLP-1 zolandilira zimawonetsedwa m'magawo aubongo omwe ndi ofunikira pakuwongolera njala. Tirzepatide imasankha kwambiri GIP yaumunthu ndi GLP-1 receptors. Tirzepatide ili ndi kuyanjana kwakukulu kwa GIP ndi GLP-1 receptors. Ntchito ya tirzepatide pa GIP receptors ndi yofanana ndi yachilengedwe ya GIP hormone. Ntchito ya tirzepatide pa GLP-1 receptors ndiyotsika kuposa yachilengedwe ya GLP-1.
Mounjaro(Tirzepatide) imagwira ntchito pochita zinthu zolandilira muubongo zomwe zimachepetsa chilakolako cha chakudya, zomwe zimakupangitsani kumva kuti ndinu okhuta, osamva njala, komanso osalakalaka chakudya. Izi zidzakuthandizani kudya pang'ono komanso kuchepetsa thupi.
Mounjaro iyenera kugwiritsidwa ntchito ndi dongosolo lazakudya zochepetsetsa komanso kuchita masewera olimbitsa thupi.
Zofunikira Zophatikiza
Mounjaro (Tirzepatide) amasonyezedwa pofuna kuchepetsa thupi, kuphatikizapo kuchepetsa thupi ndi kukonza, monga chowonjezera pa zakudya zochepetsetsa za calorie komanso kuchita masewera olimbitsa thupi kwa akuluakulu omwe ali ndi chiwerengero choyambirira cha thupi (BMI) cha:
≥ 30 kg/m2 (onenepa), kapena
≥ 27 kg/m2 mpaka <30 kg/m2 (onenepa kwambiri) wokhala ndi vuto limodzi lokhudzana ndi kulemera monga dysglycemia (prediabetes kapena mtundu wa 2 shuga), matenda oopsa, dyslipidemia, kapena kutsekeka kotsekereza kugona
Zaka 18-75 zaka
Ngati wodwala akulephera kutaya pafupifupi 5% ya kulemera kwake koyamba kwa thupi pambuyo pa miyezi 6 ya chithandizo, chigamulo chiyenera kupangidwa kuti apitirize chithandizo, poganizira ubwino / chiopsezo cha wodwalayo.
Dosing ndandanda
Mlingo woyambira wa tirzepatide ndi 2.5 mg kamodzi pa sabata. Pambuyo pa masabata a 4, mlingo uyenera kuwonjezeka kufika pa 5 mg kamodzi pa sabata. Ngati pakufunika, mlingowo ukhoza kuwonjezeka ndi 2.5 mg kwa masabata osachepera a 4 pamwamba pa mlingo wamakono.
Mlingo wokonza wovomerezeka ndi 5, 10, ndi 15 mg.
Mlingo waukulu kwambiri ndi 15 mg kamodzi pa sabata.
Dosing njira
Mounjaro(Tirzepatide) atha kuperekedwa kamodzi pa sabata nthawi iliyonse ya tsiku, kapena popanda chakudya.
Iyenera kubayidwa pansi pamimba, ntchafu, kapena kumtunda kwa mkono. Malo opangira jakisoni atha kusinthidwa. sayenera kubayidwa kudzera m'mitsempha kapena intramuscularly.
Ngati pakufunika, tsiku la mlingo wa mlungu uliwonse likhoza kusinthidwa malinga ngati nthawi yapakati pa Mlingo ndi masiku osachepera atatu (> maola 72). Tsiku latsopano la dosing likasankhidwa, kumwa kuyenera kupitilira kamodzi pa sabata.
Odwala ayenera kulangizidwa kuti awerenge mosamala malangizo ogwiritsira ntchito phukusi asanamwe mankhwala.
Nthawi yotumiza: Feb-15-2025