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Dzina lonse:Chitetezo cha mthupi -157,apentadecapeptide (15-amino acid peptide)poyamba olekanitsidwa ndi munthu chapamimba madzi.
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Amino acid mndandanda:Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, kulemera kwa maselo ≈ 1419.55 Da.
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Poyerekeza ndi ma peptide ena ambiri, BPC-157 imakhala yosasunthika m'madzi ndi madzi am'mimba, zomwe zimapangitsa kuti pakamwa kapena m'mimba zisawonongeke.
Njira Zochita
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Angiogenesis / Circulatory Recovery
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AmawongoleraChithunzi cha VEGFR-2kufotokozera, kulimbikitsa mapangidwe atsopano a mitsempha ya magazi.
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ImayatsaNjira ya Src-Caveolin-1-eNOS, zomwe zimatsogolera kumasulidwa kwa nitric oxide (NO), vasodilation, ndi ntchito yabwino ya mitsempha.
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Anti-inflammatory & Antioxidant
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Amachepetsa ma cytokines oyambitsa kutupa mongaIL-6ndiTNF-a.
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Amachepetsa kupanga kwamtundu wa oxygen (ROS), kuteteza ma cell kupsinjika kwa okosijeni.
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Kukonza Tishu
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Imalimbikitsa kuchira kwadongosolo komanso magwiridwe antchito mumitundu yovulala ya tendon, ligament, ndi minofu.
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Amapereka chitetezo cham'mimba m'mitsempha yapakati yamanjenje (kupsinjika kwa msana, cerebral ischemia-reperfusion), kuchepetsa kufa kwa neuronal ndikuwongolera kuchira kwamagalimoto / kumva.
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Kuwongolera kwa Vascular Tone
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Kafukufuku wa Ex vivo akuwonetsa kuti BPC-157 imapangitsa vasorelaxation, kutengera endothelium yokhazikika komanso NO njira.
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Zinyama & In Vitro Comparative Data
| Mtundu Woyesera | Chitsanzo / Kuthandizira | Mlingo / Administration | Kulamulira | Zotsatira zazikulu | Kuyerekeza Data |
|---|---|---|---|---|---|
| Vasodilation (matenda aorta, ex vivo) | Phenylephrine-precontracted aortic mphete | BPC-157 mpaka100 μg/ml | Palibe BPC-157 | Vasorelaxation ~37.6 ± 5.7% | Wachepetsedwa mpaka10.0 ± 5.1% / 12.3 ± 2.3%yokhala ndi NOS inhibitor (L-NAME) kapena NO scavenger (Hb) |
| Endothelial cell assay (HUVEC) | Chikhalidwe cha HUVEC | 1 μg/ml | Kulamulira kosasamalidwa | ↑ Palibe kupanga (1.35 nthawi); ↑ kusamuka kwa ma cell | Kusamuka kunathetsedwa ndi Hb |
| Ischemic limb model (khoswe) | Matenda a ischemia | 10 μg/kg/tsiku (ip) | Palibe chithandizo | Kuchira msanga kwa magazi, ↑ angiogenesis | Chithandizo > Kuwongolera |
| Kupanikizika kwa msana (khoswe) | Kupsinjika kwa msana wa Sacrococcygeal | Jekeseni imodzi ya ip 10 min pambuyo povulala | Gulu lopanda chithandizo | Kubwezeretsa kwakukulu kwa mitsempha ndi mapangidwe | Gulu lolamulira linakhalabe olumala |
| Hepatotoxicity model (CCl₄ / mowa) | Kuvulala kwachiwindi chifukwa cha mankhwala | 1 µg kapena 10 ng/kg (ip / oral) | Osathandizidwa | ↓ AST/ALT, kuchepa kwa necrosis | Gulu lolamulira linawonetsa kuvulala kwakukulu kwa chiwindi |
| Maphunziro a kawopsedwe | Mbewa, akalulu, agalu | Mlingo / njira zingapo | Zowongolera za placebo | Palibe poizoni wofunikira, palibe LD₅₀ yomwe idawonedwa | Zabwino analekerera ngakhale pa mlingo waukulu |
Maphunziro a Anthu
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Nkhani zotsatizana: Jekeseni wa intra-articular wa BPC-157 mwa odwala 12 omwe ali ndi ululu wa mawondo → 11 adanenanso kupweteka kwakukulu. Zolepheretsa: palibe gulu lolamulira, palibe chochititsa khungu, zotsatira zaumwini.
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Kuyesedwa kwachipatala: Kafukufuku wa Phase I chitetezo ndi pharmacokinetic (NCT02637284) mwa odzipereka athanzi a 42 adachitidwa, koma zotsatira sizinasindikizidwe.
Panopa,palibe mayesero apamwamba kwambiri (RCTs)zilipo kuti zitsimikizire mphamvu zachipatala komanso chitetezo.
Chitetezo & Zowopsa Zomwe Zingachitike
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Angiogenesis: Imathandiza kuchiritsa, koma imatha kulimbikitsa kukula kwa chotupa, kufulumizitsa kukula kapena metastasis mwa odwala khansa.
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Mlingo & Administration: Kuchita bwino kwa nyama pamiyeso yotsika kwambiri (ng–µg/kg), koma mlingo woyenera wa anthu ndi njira sizidziwika.
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Kugwiritsa ntchito nthawi yayitali: Palibe chidziwitso chokwanira chautali wautali; maphunziro ambiri ndi akanthawi kochepa.
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Mkhalidwe wowongolera: Osavomerezedwa ngati mankhwala m'maiko ambiri; ogawidwa ngati achinthu choletsedwandi WADA (World Anti-Doping Agency).
Kuyerekeza Kuzindikira & Zochepa
| Kuyerekezera | Mphamvu | Zolepheretsa |
|---|---|---|
| Zinyama vs Anthu | Zopindulitsa zokhazikika mu nyama (tendon, mitsempha, kukonza chiwindi, angiogenesis) | Umboni waumunthu ndi wochepa, wosalamulirika, ndipo ulibe kutsata kwa nthawi yaitali |
| Mtundu wa mlingo | Kuchita bwino pamilingo yotsika kwambiri pazinyama (ng-µg/kg; µg/ml mu m'galasi) | Mlingo wotetezedwa/wothandiza wa munthu sudziwika |
| Chiyambi cha zochita | Kukonzekera koyambirira kovulaza (mwachitsanzo, 10 min pambuyo pa kuvulala kwa msana) kumabweretsa kuchira kwamphamvu | Kuthekera kwachipatala kwa nthawi yotere sikudziwika bwino |
| Poizoni | Palibe mlingo wakupha kapena zotsatira zoyipa zomwe zimawonedwa mumitundu ingapo ya nyama | Kuopsa kwa nthawi yayitali, carcinogenicity, ndi chitetezo cha uchembere sichinayesedwe |
Mapeto
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BPC-157 imawonetsa zotsatira zamphamvu zotsitsimutsa komanso zoteteza mumitundu yanyama ndi ma cell: angiogenesis, anti-kutupa, kukonza minofu, neuroprotection, ndi hepatoprotection.
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Umboni wa anthu ndi wochepa kwambiri, popanda chidziwitso champhamvu chachipatala chomwe chilipo.
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Komansoopangidwa mwachisawawa mayesero olamulidwaamayenera kukhazikitsa mphamvu, chitetezo, mlingo woyenera, ndi njira zoyendetsera anthu.
Nthawi yotumiza: Sep-23-2025