Mbiri
Mankhwala opangidwa ndi inretin akhala akudziwika kale kuti amawongolera onse awirikuwongolera shuga wamagazindikuchepetsa thupi. Mankhwala achikhalidwe a incretin amayang'ana kwambiriGLP-1 receptor, pameneTirzepatideikuyimira m'badwo watsopano "twincretin” othandizira - kuchitapo kanthuGIP (yodalira glucose-insulinotropic polypeptide)ndiGLP-1ma receptors.
Kuchita kwapawiri kumeneku kwawonetsedwa kuti kumawonjezera phindu la kagayidwe kachakudya komanso kulimbikitsa kuchepa thupi kwambiri poyerekeza ndi ma agonist a GLP-1 okha.
Mapangidwe a Phunziro la SURMOUNT-1
SURMOUNT-1anali akuyesedwa kosasinthika, kawiri-khungu, gawo lachitatu lachipatalaidachitika pamasamba 119 m'maiko asanu ndi anayi.
Otenga nawo mbali anali akuluakulu omwe anali:
- onenepa(BMI ≥30), kapena
- Kunenepa kwambiri(BMI ≥ 27) yokhala ndi matenda osachepera amodzi okhudzana ndi kulemera (mwachitsanzo, kuthamanga kwa magazi, dyslipidemia, kupuma movutikira, kapena matenda amtima).
Anthu omwe ali ndi matenda a shuga, kugwiritsa ntchito mankhwala osokoneza bongo posachedwa, kapena opaleshoni yam'mbuyo ya bariatric sanaphatikizidwe.
Otenga nawo mbali adapatsidwa mwayi wolandira jakisoni kamodzi pa sabata:
- Tirzepatide 5 mg, 10 mg pa, 15 mg pa, kapena
- Malo
Onse omwe adatenga nawo mbali adalandiranso chitsogozo cha moyo:
- A calorie akusowa 500 kcal / tsiku
- OsacheperaKuchita masewera olimbitsa thupi kwa mphindi 150 pa sabata
Chithandizocho chinatha72 masabata, kuphatikizapo a20-masabata owonjezera mlingo-kukweza gawokutsatiridwa ndi nthawi yokonza masabata 52.
Zotsatira Mwachidule
Chiwerengero cha2,359 otenga nawo mbalianalembedwa.
M'badwo wapakati unalizaka 44.9, 67.5% anali akazi, ndi mphamvukulemera kwa thupi 104.8 kgndiBMI ya 38.0.
Kuchepetsa Kulemera Kwa Thupi Pa Sabata 72
| Gulu la Mlingo | % Kusintha kwa Thupi | Kusintha Kunenepa Kwambiri (kg) | Zowonjezera Zotayika vs Placebo |
|---|---|---|---|
| 5 mg pa | -15.0% | - 16.1 kg | -13.5% |
| 10 mg pa | -19.5% | - 22.2 kg | -18.9% |
| 15 mg pa | -20.9% | - 23.6 kg | -20.1% |
| Malo | -3.1% | - 2.4 kg | - |
Tirzepatide adapeza 15-21% amatanthauza kuchepetsa thupi, kusonyeza zotsatira zomveka zodalira mlingo.
Peresenti ya Ophunzira Amene Akuchepetsa Kuwonda Zomwe Amafuna
| Kuonda (%) | 5 mg pa | 10 mg pa | 15 mg pa | Malo |
|---|---|---|---|---|
| ≥5% | 85.1% | 88.9% | 90.9% | 34.5% |
| ≥10% | 68.5% | 78.1% | 83.5% | 18.8% |
| ≥15% | 48.0% | 66.6% | 70.6% | 8.8% |
| ≥20% | 30.0% | 50.1% | 56.7% | 3.1% |
| ≥25% | 15.3% | 32.3% | 36.2% | 1.5% |
Zoposa thekaza omwe akulandira≥10 mgTirzepatide yakwaniritsidwa≥20% kuchepa thupi, kuyandikira zotsatira zomwe zimawonedwa ndi opaleshoni ya bariatric.
Ubwino wa Metabolic ndi Cardiovascular Benefits
Poyerekeza ndi placebo, Tirzepatide idachita bwino kwambiri:
- Kuzungulira m'chiuno
- Kuthamanga kwa magazi kwa systolic
- Mbiri ya lipid
- Kuchepetsa kuchuluka kwa insulin
Pakati pa omwe ali nawoprediabetes, 95.3% yabwerera ku milingo yabwinobwino ya glucose, kuyelekeza ndi61.9%m'gulu la placebo - zomwe zikuwonetsa kuti Tirzepatide sikuti imangothandiza kuchepetsa thupi komanso imathandizira kagayidwe ka glucose.
Chitetezo ndi Kulekerera
Zotsatira zofala kwambiri zinalim'mimba, kuphatikizaponseru, kutsegula m'mimba, ndi kudzimbidwa, makamaka yofatsa komanso yosakhalitsa.
Mlingo wosiya chifukwa cha zochitika zoyipa zinali pafupifupi4-7%.
Imfa zowerengeka zidachitika panthawi ya mlandu, zomwe zimalumikizidwa ndiCOVID 19, ndipo sizinali zogwirizana mwachindunji ndi mankhwala ophunzirira.
Palibe kusiyana kwakukulu komwe kunawonedwa pazovuta zokhudzana ndi ndulu.
Zokambirana
Kusintha kwa moyo kokha (zakudya ndi masewera olimbitsa thupi) kumapanga kokha~ 3% kulemera kwapakati, monga zikuwonekera mu gulu la placebo.
Mosiyana ndi zimenezi, Tirzepatide inathandiza15-21% kuchepetsa kulemera kwa thupi, kuimira a5-7 zina zazikulu kwenikweni.
Poyerekeza ndi:
- Mankhwala ochepetsa thupi mkamwa:nthawi zambiri amapeza kutaya kwa 5-10%.
- Opaleshoni ya Bariatric:amakwaniritsa > 20% kutaya
Tirzepatide imatsekereza kusiyana pakati pa pharmacologic ndi maopaleshoni - kuperekakuchepetsa kulemera kwamphamvu, kosasokoneza.
Chofunika kwambiri, nkhawa zakuwonjezereka kwa glucose metabolism sizinawonekere. M'malo mwake, Tirzepatide idakulitsa chidwi cha insulin ndikusinthiratu prediabetes mwa ambiri omwe adatenga nawo gawo.
Komabe, kuyesaku kuyerekeza Tirzepatide ndi placebo - osati mwachindunjiSemaglutide.
Kuyerekeza kwa mutu ndi mutu kumafunika kuti mudziwe kuti ndi wothandizira ati amene amatulutsa kulemera kwakukulu.
Mapeto
Kwa akuluakulu omwe ali ndi kunenepa kwambiri kapena kunenepa kwambiri komanso zofananira nazo, kuwonjezeraTirzepatide kamodzi pamlunguku pulogalamu yokhazikika yamoyo (zakudya + zolimbitsa thupi) zitha kubweretsa ku:
- 15-21% kuchepetsa kulemera kwa thupi
- Kusintha kwakukulu kwa metabolic
- High tolerability ndi chitetezo
Tirzepatide motero imayimira chithandizo chovomerezeka komanso chovomerezeka chachipatala chokhazikika, choyang'aniridwa ndichipatala.
Nthawi yotumiza: Oct-16-2025