M'zaka zaposachedwa, ma GLP-1 receptor agonists adakula mwachangu kuchoka pamankhwala a shuga kupita ku zida zowongolera zolimbitsa thupi, ndikukhala gawo limodzi mwamagawo omwe amawonedwa kwambiri pazamankhwala padziko lonse lapansi. Pofika pakati pa 2025, kukwera uku sikukuwonetsa kuchepa. Zimphona zazikulu zamakampani Eli Lilly ndi Novo Nordisk akuchita mpikisano waukulu, makampani opanga mankhwala aku China akuchulukirachulukira padziko lonse lapansi, ndipo zolinga zatsopano ndi zisonyezo zikupitilirabe. GLP-1 siilinso gulu lamankhwala - ikusintha kukhala nsanja yokwanira yowongolera matenda a metabolic.
Tirzepatide ya Eli Lilly yapereka zotsatira zochititsa chidwi m'mayesero akulu akulu azachipatala amtima, zomwe zikuwonetsa kuti sikugwira ntchito mokhazikika mu shuga wamagazi komanso kuchepetsa thupi, komanso chitetezo chapamwamba chamtima. Owonera ambiri ogulitsa amawona ichi ngati chiyambi cha "kukula kwachiwiri" kwamankhwala a GLP-1. Pakadali pano, Novo Nordisk ikukumana ndi mphepo yamkuntho-kuchepetsa kugulitsa, kutsika kwa ndalama, komanso kusintha kwa utsogoleri. Mpikisano womwe uli mu danga la GLP-1 wasintha kuchoka ku "nkhondo za blockbuster" kupita ku mpikisano wokwanira wachilengedwe chonse.
Kupatula jekeseni, mapaipi ndi osiyanasiyana. Mapangidwe a pakamwa, mamolekyu ang'onoang'ono, ndi mankhwala ophatikizana akupangidwa ndi makampani osiyanasiyana, onse akufuna kupititsa patsogolo kumvera kwa odwala ndikuwonekera pamsika wodzaza anthu. Panthawi imodzimodziyo, makampani opanga mankhwala aku China akuwonetsa mwakachetechete kupezeka kwawo, akumapeza malayisensi apadziko lonse a madola mabiliyoni ambiri—chizindikiro cha kukwera kwamphamvu kwa China pakupanga mankhwala atsopano.
Chofunika koposa, mankhwala a GLP-1 akupitilira kunenepa kwambiri komanso matenda a shuga. Matenda amtima, matenda a chiwindi amafuta osamwa mowa (NAFLD), matenda a Alzheimer's, kuledzera, ndi vuto la kugona tsopano akufufuzidwa, ndi umboni wochulukirapo wosonyeza kuthekera kwa GLP-1 m'malo awa. Ngakhale ambiri mwa mapulogalamuwa akadali oyambilira, akukopa ndalama zambiri zofufuza komanso chidwi chachikulu.
Komabe, kutchuka komwe kukukula kwamankhwala a GLP-1 kumabweretsanso nkhawa zachitetezo. Malipoti aposachedwa okhudzana ndi kugwiritsidwa ntchito kwa nthawi yayitali kwa GLP-1 ku zovuta zamano komanso zovuta za mitsempha yamaso zakweza mbendera zofiira pakati pa anthu onse ndi owongolera. Kuyanjanitsa bwino ndi chitetezo kudzakhala kofunika kwambiri pakukula kwamakampani.
Zonse zikaganiziridwa, GLP-1 sichirinso njira yothandizira - yakhala bwalo lankhondo lapakati pa mpikisano wofotokozera tsogolo la thanzi la metabolic. Kuchokera pazatsopano zasayansi mpaka kusokonezeka kwa msika, kuchokera kumitundu yatsopano yobweretsera kupita kukugwiritsa ntchito matenda ambiri, GLP-1 simankhwala chabe - ndi mwayi wopezeka.
Nthawi yotumiza: Aug-01-2025