Semaglutide yakopa chidwi chachikulu pakuchita bwino pakuwongolera kulemera

Monga GLP-1 agonist, imatsanzira momwe thupi limakhalira ndi GLP-1 yotulutsidwa mwachilengedwe m'thupi.

Poyankha kudya kwa shuga, ma PPG neurons mu dongosolo lapakati lamanjenje (CNS) ndi L-maselo m'matumbo amatulutsa ndikutulutsa GLP-1, mahomoni oletsa m'mimba.

Ikatulutsidwa, GLP-1 imayambitsa zolandilira za GLP-1R pama cell β-cell, ndikuyambitsa kusintha kwa kagayidwe kachakudya komwe kamadziwika ndi katulutsidwe ka insulini komanso kupondereza kudya.

Kutulutsa kwa insulin kumabweretsa kutsika kwa shuga m'magazi, kutsika kwa glucagon, ndikuletsa kutulutsidwa kwa shuga m'magawo a glycogen a chiwindi. Izi zimathandizira kukhuta, kukulitsa chidwi cha insulin, ndipo pamapeto pake kumachepetsa thupi.

Mankhwalawa amathandizira katulutsidwe ka insulini m'njira yodalira shuga, motero amachepetsa chiopsezo cha hypoglycemia. Kuphatikiza apo, imakhala ndi zotsatira zabwino za nthawi yayitali pa kupulumuka, kufalikira, ndi kusinthika kwa ma β-cell.

Kafukufuku akuwonetsa kuti semaglutide makamaka amatsanzira zomwe GLP-1 imatulutsidwa m'matumbo osati muubongo. Izi ndichifukwa choti ma receptor ambiri a GLP-1 muubongo amakhala kunja kwa mankhwala omwe amayendetsedwa mwadongosolo. Ngakhale kuti imachepa mwachindunji paubongo wa GLP-1 receptors, semaglutide imakhalabe yothandiza kwambiri pochepetsa kudya komanso kulemera kwa thupi.

Zikuwoneka kuti zikwaniritsa izi poyambitsa ma netiweki a neuronal kudutsa pakati pa mitsempha yapakati, ambiri omwe ndi zolinga zachiwiri zomwe siziwonetsa mwachindunji zolandilira za GLP-1.

Mu 2024, mitundu yovomerezeka yamalonda ya semaglutide ikuphatikizaOzempic, Rybelsus,ndiWegovyjakisoni, onse opangidwa ndi Novo Nordisk.