Retatrutide ikusintha momwe kunenepa kumachitidwira

Masiku ano, kunenepa kwambiri kwakhala vuto lathanzi padziko lonse lapansi, komanso kutuluka kwaRetatrutideimapereka chiyembekezo chatsopano kwa odwala omwe akulimbana ndi kunenepa kwambiri. Retatrutide ndikatatu receptor agonistkulunjikaGLP-1R, GIPR, ndi GCGR. Kachitidwe kapadera kameneka kamene kamakhala ndi zolinga zambiri kumawonetsa kuthekera kwakukulu kochepetsa thupi.

Mwanjira, Retatrutide imayambaGLP-1 receptors, zomwe zimathandizira kutulutsa kwa insulini, kupondereza kutulutsidwa kwa glucagon, ndikuchedwetsa kutulutsa m'mimba, motero kumawonjezera kukhuta ndikuchepetsa kudya. Kutsegula kwake kwaGIP receptorskumapangitsanso chidwi cha insulin, kuwongolera kagayidwe ka lipid, ndikugwira ntchito mogwirizana ndi GLP-1 kukulitsa zotsatira zochepetsa thupi. Chofunika kwambiri, kuyambitsa kwake kwaglucagon receptors (GCGR)kumawonjezera ndalama zogwiritsira ntchito mphamvu, kumawonjezera kulepheretsa kwa chiwindi cha gluconeogenesis, ndi kuchepetsa kuchuluka kwa mafuta m'chiwindi-pamodzi, njirazi zimathandizira kuchepetsa kulemera kwakukulu.

M'mayesero azachipatala, kuchepa kwa thupi kwa Retatrutide kwakhala kodabwitsa. Mu kafukufuku wachipatala wa masabata a 48 Phase 2, omwe adalandira 12 mg ya Retatrutide mlungu uliwonse adataya pafupifupi24.2% ya kulemera kwa thupi lawo-zotsatira zomwe zimaposa kwambiri mankhwala ambiri ochepetsa thupi ndikuyandikira mphamvu ya opaleshoni ya bariatric. Komanso, kuchepa kwa thupi kumapitirirabe bwino pakapita nthawi; mwasabata 72, pafupifupi kuchepetsa kulemera kunafika pafupifupi28%.

Kupitilira mphamvu yake yochepetsera zolemetsa, Retatrutide ikuwonetsanso lonjezo lalikulu pakuwongolera zovuta zokhudzana ndi kunenepa kwambiri. Itha kutsitsa kuthamanga kwa magazi, kuwongolera mbiri yamafuta amafuta, kuchepetsa kuchuluka kwa triglyceride, komanso kupereka chitetezo chamtima - kubweretsa chitetezo.ubwino wathanzi wathanzikwa anthu okhala ndi kunenepa kwambiri.