Tirzepatide, novel dual receptor agonist (GLP-1 / GIP), yakopa chidwi kwambiri m'zaka zaposachedwa chifukwa cha gawo lake pochiza matenda a shuga. Komabe, kuthekera kwake mu matenda amtima ndi aimpso kumayamba pang'onopang'ono. Kafukufuku waposachedwa akuwonetsa kuti tirzepatide ikuwonetsa kuchita bwino kwa odwala omwe ali ndi vuto la mtima ndi kagawo kakang'ono ka ejection (HFpEF) kuphatikiza kunenepa kwambiri komanso matenda a impso (CKD). Mayesero achipatala a SUMMIT adawonetsa kuti odwala omwe amalandila tirzepatide adachepetsa ndi 38% chiopsezo cha kufa kwa mtima kapena kulephera kwa mtima kukulirakulira mkati mwa milungu 52, pomwe zizindikiro za aimpso monga eGFR zidakula kwambiri. Kupezeka kumeneku kumapereka njira yatsopano yochizira odwala omwe ali ndi vuto la metabolic.
M'munda wamtima, njira ya tirzepatide imapitilira kuwongolera kagayidwe kachakudya. Poyambitsa onse GLP-1 ndi GIP receptors, amachepetsa kuchuluka kwa adipocytes, potero amachepetsa kuthamanga kwa minofu yamafuta pamtima ndikuwongolera mphamvu ya myocardial metabolism ndi anti-ischemic mphamvu. Kwa odwala a HFpEF, kunenepa kwambiri ndi kutupa kosatha ndizofunikira kwambiri, ndipo kuyambitsa kwapawiri kwa tirzepatide kumapondereza kutulutsa kwa cytokine ndikuchepetsa myocardial fibrosis, potero kuchedwetsa kuwonongeka kwa mtima. Kuonjezera apo, imapangitsa kuti anthu ambiri azikhala ndi moyo wabwino (monga KCCQ-CSS) ndi mphamvu zolimbitsa thupi.
Tirzepatide imawonetsanso zolimbikitsa pakuteteza aimpso. CKD nthawi zambiri imatsagana ndi kusokonezeka kwa metabolic komanso kutupa kwapang'onopang'ono. The mankhwala amachita mwa wapawiri njira: kusintha glomerular hemodynamics kuchepetsa proteinuria, ndi mwachindunji inhibiting ndondomeko aimpso fibrosis. M'mayesero a SUMMIT, tirzepatide idakulitsa kwambiri milingo ya eGFR yotengera cystatin C ndikuchepetsa albuminuria mosasamala kanthu kuti odwala anali ndi CKD, zomwe zikuwonetsa chitetezo chokwanira chaimpso. Kupeza uku kumapereka njira yatsopano yochizira matenda a shuga a nephropathy ndi matenda ena a impso.
Chochititsa chidwi kwambiri ndi kufunikira kwapadera kwa tirzepatide mwa odwala omwe ali ndi "utatu" wa kunenepa kwambiri, HFpEF, ndi CKD - gulu lomwe silinadziwe bwino za matendawa. Tirzepatide imapangitsa kuti thupi liziyenda bwino (kuchepetsa kuchuluka kwa mafuta ndikupititsa patsogolo kagayidwe kachakudya ka minofu) ndikuwongolera njira zotupa, potero zimapereka chitetezo chogwirizana pazigawo zingapo. Pamene zisonyezo za tirzepatide zikupitilira kukula, yatsala pang'ono kukhala chithandizo chapangodya pakuwongolera matenda a metabolic omwe ali ndi comorbidities.
Nthawi yotumiza: Jul-21-2025