MOTS-c: Peptide ya Mitochondrial yokhala ndi Mapindu Olonjeza Paumoyo

MOTS-c (Mitochondrial Open Reading Frame ya 12S rRNA Type-c) ndi peptide yaying'ono yosungidwa ndi DNA ya mitochondrial yomwe yakopa chidwi cha asayansi m'zaka zaposachedwa. Mwachikhalidwe, mitochondria imawonedwa makamaka ngati "mphamvu ya cell," yomwe imayang'anira kupanga mphamvu. Komabe, kafukufuku wotulukapo akuwonetsa kuti mitochondria imagwiranso ntchito ngati malo owonetsera, kuyang'anira kagayidwe kazakudya ndi thanzi la ma cell kudzera pa ma peptides a bioactive monga MOTS-c.

Peptide iyi, yopangidwa ndi ma amino acid 16 okha, imayikidwa mkati mwa 12S rRNA dera la mitochondrial DNA. Akapangidwa mu cytoplasm, amatha kulowa mkati, komwe amakhudza mawonekedwe a majini omwe amakhudzidwa ndi kagayidwe kachakudya. Imodzi mwamaudindo ake ofunikira ndikuyambitsa njira yolumikizira ya AMPK, yomwe imapangitsa kuti shuga atengeke komanso kugwiritsidwa ntchito kwake ndikuwonjezera chidwi cha insulin. Izi zimapangitsa MOTS-c kukhala munthu wodalirika wothana ndi zovuta za metabolic monga mtundu wa 2 shuga komanso kunenepa kwambiri.

Kupitilira kagayidwe kazakudya, MOTS-c yawonetsa zoteteza ku kupsinjika kwa okosijeni polimbitsa chitetezo cha cell komanso kuchepetsa kuwonongeka komwe kumachitika chifukwa cha ma free radicals. Ntchitoyi imathandizira kukhalabe ndi thanzi la ziwalo zofunika kwambiri monga mtima, chiwindi, ndi dongosolo lamanjenje. Kafukufuku wawonetsanso mgwirizano womveka bwino pakati pa milingo ya MOTS-c ndi ukalamba: thupi likamakula, milingo yachilengedwe ya peptide imachepa. Kuonjezera pa maphunziro a zinyama kwathandiza kuti thupi liziyenda bwino, kuchedwetsa kuchepa kwa zaka, komanso moyo wautali, zomwe zimapangitsa kuti MOTS-c ipangidwe ngati "molekyu yotsutsa kukalamba."

Kuphatikiza apo, MOTS-c ikuwoneka kuti imathandizira kagayidwe kake ka minofu ndi kupirira, zomwe zimapangitsa chidwi kwambiri pamankhwala amasewera ndi kukonzanso. Kafukufuku wina akuwonetsanso zabwino zomwe zingachitike pamatenda a neurodegenerative, ndikukulitsa chiwongolero chake chamankhwala.

Ngakhale akadali koyambirira kwa kafukufuku, MOTS-c ikuyimira kupita patsogolo pakumvetsetsa kwathu kwa biology ya mitochondrial. Sikuti zimangotsutsa malingaliro ochiritsira a mitochondria komanso zimatsegula njira zatsopano zochizira matenda a kagayidwe kachakudya, kuchepetsa ukalamba, ndi kulimbikitsa thanzi labwino. Ndi maphunziro owonjezereka komanso chitukuko chachipatala, MOTS-c ikhoza kukhala chida champhamvu m'tsogolomu zamankhwala.