Zizindikiro ndi kufunika kwachipatala kwa jakisoni wa Tirzepatide

Tirzepatidendi novel agonist wapawiri wa GIP ndi GLP-1 receptors, wovomerezeka kuti aziwongolera glycemic mwa akulu omwe ali ndi matenda amtundu wa 2 komanso kuwongolera kulemera kwanthawi yayitali mwa anthu omwe ali ndi index yayikulu ya thupi (BMI) ≥30 kg/m², kapena ≥27 kg/m² omwe ali ndi vuto limodzi lokhudzana ndi kulemera.

Kwa matenda a shuga, amachepetsa kusala kudya komanso kwa postprandial glucose pochedwetsa kutulutsa m'mimba, kukulitsa katulutsidwe ka insulini yodalira shuga, komanso kupondereza kutulutsidwa kwa glucagon, zomwe zimakhala ndi chiopsezo chochepa cha hypoglycemia poyerekeza ndi ma secretagogue achikhalidwe a insulin. Poyang'anira kunenepa kwambiri, zochita zake ziwiri zapakati ndi zotumphukira zimachepetsa chilakolako ndikuwonjezera kugwiritsa ntchito mphamvu. Mayesero azachipatala awonetsa kuti masabata a 52-72 a chithandizo amatha kuchepetsa kulemera kwa thupi kwa 15% -20%, limodzi ndi kusintha kwa chiuno, kuthamanga kwa magazi, ndi triglycerides.

Zoyipa zomwe zimachitika kwambiri ndizomwe zimachitika pang'onopang'ono mpaka pang'onopang'ono, zomwe zimachitika m'masabata angapo oyamba ndipo zimachepetsedwa pang'onopang'ono. Kuyamba kwachipatala kumalimbikitsidwa poyang'aniridwa ndi endocrinologist kapena katswiri wowongolera kulemera, ndikuwunika kosalekeza kwa shuga, kulemera kwa thupi, ndi ntchito yaimpso. Ponseponse, tirzepatide imapereka njira yochiritsira yokhazikika, yotetezeka, komanso yokhazikika kwa odwala omwe amafunikira kuwongolera glycemic komanso kulemera.